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• W2127788612 abstract "<h3>Background</h3> The transforming capacities of <i>RET</i> and/or <i>NTRK</i>1 chimeric oncogenes as well as the molecular background of non-rearranged papillary thyroid carcinomas (PTCs) remain to be elucidated. To assess altered gene expression, we examined PTCs with and without tyrosine kinase receptor rearrangements by mRNA differential display (DD). <h3>Materials and methods</h3> Six of 13 PTCs examined harbored <i>RET</i> chimeras (3× RET/PTC1, 1× RET/PTC3) and/or <i>NTRK</i>1 chimeras (2× trk, 1× TRK-T3, 2 unknown TRK hybrids). The method of DD analysis was refined by a novel fragment-recovery technique using a high-performance fluorescence scanner. <h3>Results</h3> Of 500 up- or down-regulated mRNA transcripts, 19 selected fragments were recovered, cloned, sequenced, and identified. The accuracy and high degree of reproducibility of the method was demonstrated. Differential expression of gene products with potential association to cell proliferation or tumor progression was observed, such as 14-3-3beta and Rab27a. Moreover, several gene products with unknown functions were demonstrated in PTCs bearing <i>RET</i> or <i>NTRK</i>1 hybrids <i>versus</i> rearrangement-negative PTCs, including a homologue of the Ig kappa light chain constant region. <h3>Conclusions</h3> Candidate transcripts with presumed tumorigenic potential in other solid tumors may prove to be relevant in the progression of PTCs, too. Most promising is the isolation of several differentially expressed, yet unknown, genes that may open new insights in the pathogenesis or progression of PTC." @default.
• W2127788612 created "2016-06-24" @default.
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• W2127788612 date "2006-03-01" @default.
• W2127788612 modified "2023-09-30" @default.
• W2127788612 title "Identification of Differentially Expressed Genes in Papillary Thyroid Carcinomas With and Without Rearrangements of the Tyrosine Kinase Receptors RET and/or NTRK1" @default.
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• W2127788612 doi "https://doi.org/10.1016/j.jss.2005.08.013" @default.
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