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- W2127788986 abstract "The properties of several components of outward K + currents, including the pharmacological and kinetics profiles as well as the respective molecular correlates, have been identified in mouse cardiac myocytes. Surprisingly little is known with regard to the Ca 2+ -activated ionic currents. We studied the Ca 2+ -activated transient outward currents in mouse ventricular myocytes. We have identified a 4-aminopyridine (4-AP)- and tetraethyl ammonium-resistant transient outward current that is Ca 2+ dependent. The current is carried by Cl − and is critically dependent on Ca 2+ influx via voltage-gated Ca 2+ channels and the sarcoplasmic reticulum Ca 2+ store. The current can be blocked by the anion transport blockers niflumic acid and 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid. Single channel recordings reveal small conductance channels (∼1 pS in 140 mM Cl − ) that can be blocked by anion transport blockers. Ensemble-averaged current faithfully mirrors the transient kinetics observed at the whole level. Niflumic acid (in the presence of 4-AP) leads to prolongation of the early repolarization. Thus this current may contribute to early repolarization of action potentials in mouse ventricular myocytes." @default.
- W2127788986 created "2016-06-24" @default.
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- W2127788986 date "2002-07-01" @default.
- W2127788986 modified "2023-10-15" @default.
- W2127788986 title "Presence of a calcium-activated chloride current in mouse ventricular myocytes" @default.
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- W2127788986 doi "https://doi.org/10.1152/ajpheart.00044.2002" @default.
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