FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127807241> ?p ?o ?g. }

• W2127807241 endingPage "E1715" @default.
• W2127807241 startingPage "E1709" @default.
• W2127807241 abstract "A fatty liver is associated with fasting hyperinsulinemia, which could reflect either impaired insulin clearance or hepatic insulin action. We determined the effect of liver fat on insulin clearance and hepatic insulin sensitivity in 80 nondiabetic subjects [age 43 +/- 1 yr, body mass index (BMI) 26.3 +/- 0.5 kg/m(2)]. Insulin clearance and hepatic insulin resistance were measured by the euglycemic hyperinsulinemic (insulin infusion rate 0.3 mU.kg(-1).min(-1) for 240 min) clamp technique combined with the infusion of [3-(3)H]glucose and liver fat by proton magnetic resonance spectroscopy. During hyperinsulinemia, both serum insulin concentrations and increments above basal remained approximately 40% higher (P < 0.0001) in the high (15.0 +/- 1.5%) compared with the low (1.8 +/- 0.2%) liver fat group, independent of age, sex, and BMI. Insulin clearance (ml.kg fat free mass(-1).min(-1)) was inversely related to liver fat content (r = -0.52, P < 0.0001), independent of age, sex, and BMI (r = -0.37, P = 0.001). The variation in insulin clearance due to that in liver fat (range 0-41%) explained on the average 27% of the variation in fasting serum (fS)-insulin concentrations. The contribution of impaired insulin clearance to fS-insulin concentrations increased as a function of liver fat. This implies that indirect indexes of insulin sensitivity, such as homeostatic model assessment, overestimate insulin resistance in subjects with high liver fat content. Liver fat content correlated significantly with fS-insulin concentrations adjusted for insulin clearance (r = 0.43, P < 0.0001) and with directly measured hepatic insulin sensitivity (r = -0.40, P = 0.0002). We conclude that increased liver fat is associated with both impaired insulin clearance and hepatic insulin resistance. Hepatic insulin sensitivity associates with liver fat content, independent of insulin clearance." @default.
• W2127807241 created "2016-06-24" @default.
• W2127807241 creator A5028953583 @default.
• W2127807241 creator A5029268686 @default.
• W2127807241 creator A5057333824 @default.
• W2127807241 creator A5085096307 @default.
• W2127807241 creator A5085730760 @default.
• W2127807241 date "2007-12-01" @default.
• W2127807241 modified "2023-10-16" @default.
• W2127807241 title "Effect of liver fat on insulin clearance" @default.
• W2127807241 cites W1978027514 @default.
• W2127807241 cites W1983498250 @default.
• W2127807241 cites W1984033419 @default.
• W2127807241 cites W2004052309 @default.
• W2127807241 cites W2012492644 @default.
• W2127807241 cites W2023294484 @default.
• W2127807241 cites W2044482587 @default.
• W2127807241 cites W2051587973 @default.
• W2127807241 cites W2065544193 @default.
• W2127807241 cites W2072271848 @default.
• W2127807241 cites W2083350111 @default.
• W2127807241 cites W2093071246 @default.
• W2127807241 cites W2107068945 @default.
• W2127807241 cites W2108916652 @default.
• W2127807241 cites W2109469243 @default.
• W2127807241 cites W2109555667 @default.
• W2127807241 cites W2112538182 @default.
• W2127807241 cites W2113979297 @default.
• W2127807241 cites W2114654514 @default.
• W2127807241 cites W2123521914 @default.
• W2127807241 cites W2124232607 @default.
• W2127807241 cites W2127439265 @default.
• W2127807241 cites W2129686285 @default.
• W2127807241 cites W2129694420 @default.
• W2127807241 cites W2132477505 @default.
• W2127807241 cites W2132705610 @default.
• W2127807241 cites W2136587235 @default.
• W2127807241 cites W2138287225 @default.
• W2127807241 cites W2143357266 @default.
• W2127807241 cites W2152998449 @default.
• W2127807241 cites W2159469729 @default.
• W2127807241 cites W2159896083 @default.
• W2127807241 cites W2160234571 @default.
• W2127807241 cites W2163235578 @default.
• W2127807241 cites W2168141798 @default.
• W2127807241 cites W2186184337 @default.
• W2127807241 cites W2319607702 @default.
• W2127807241 cites W2418805933 @default.
• W2127807241 cites W2615637571 @default.
• W2127807241 cites W4245577901 @default.
• W2127807241 doi "https://doi.org/10.1152/ajpendo.00444.2007" @default.
• W2127807241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17895288" @default.
• W2127807241 hasPublicationYear "2007" @default.
• W2127807241 type Work @default.
• W2127807241 sameAs 2127807241 @default.
• W2127807241 citedByCount "186" @default.
• W2127807241 countsByYear W21278072412012 @default.
• W2127807241 countsByYear W21278072412013 @default.
• W2127807241 countsByYear W21278072412014 @default.
• W2127807241 countsByYear W21278072412015 @default.
• W2127807241 countsByYear W21278072412016 @default.
• W2127807241 countsByYear W21278072412017 @default.
• W2127807241 countsByYear W21278072412018 @default.
• W2127807241 countsByYear W21278072412019 @default.
• W2127807241 countsByYear W21278072412020 @default.
• W2127807241 countsByYear W21278072412021 @default.
• W2127807241 countsByYear W21278072412022 @default.
• W2127807241 countsByYear W21278072412023 @default.
• W2127807241 crossrefType "journal-article" @default.
• W2127807241 hasAuthorship W2127807241A5028953583 @default.
• W2127807241 hasAuthorship W2127807241A5029268686 @default.
• W2127807241 hasAuthorship W2127807241A5057333824 @default.
• W2127807241 hasAuthorship W2127807241A5085096307 @default.
• W2127807241 hasAuthorship W2127807241A5085730760 @default.
• W2127807241 hasConcept C126322002 @default.
• W2127807241 hasConcept C134018914 @default.
• W2127807241 hasConcept C185592680 @default.
• W2127807241 hasConcept C2777391703 @default.
• W2127807241 hasConcept C2778024521 @default.
• W2127807241 hasConcept C2778808658 @default.
• W2127807241 hasConcept C2779306644 @default.
• W2127807241 hasConcept C2780352109 @default.
• W2127807241 hasConcept C2780988686 @default.
• W2127807241 hasConcept C71924100 @default.
• W2127807241 hasConceptScore W2127807241C126322002 @default.
• W2127807241 hasConceptScore W2127807241C134018914 @default.
• W2127807241 hasConceptScore W2127807241C185592680 @default.
• W2127807241 hasConceptScore W2127807241C2777391703 @default.
• W2127807241 hasConceptScore W2127807241C2778024521 @default.
• W2127807241 hasConceptScore W2127807241C2778808658 @default.
• W2127807241 hasConceptScore W2127807241C2779306644 @default.
• W2127807241 hasConceptScore W2127807241C2780352109 @default.
• W2127807241 hasConceptScore W2127807241C2780988686 @default.
• W2127807241 hasConceptScore W2127807241C71924100 @default.
• W2127807241 hasIssue "6" @default.
• W2127807241 hasLocation W21278072411 @default.
• W2127807241 hasLocation W21278072412 @default.
• W2127807241 hasOpenAccess W2127807241 @default.

• next