FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127810225> ?p ?o ?g. }

• W2127810225 endingPage "2961" @default.
• W2127810225 startingPage "2955" @default.
• W2127810225 abstract "Rac1 is a Ρ-family GTP-binding protein that controls lamellipodia formation and membrane ruffling in fibroblasts. Recently, Rac1 and Cdc42, another member of the Ρ-family, have been shown to regulate Fc receptor-mediated phagocytosis in macrophages by controlling different steps of membrane and actin dynamics leading to particle engulfment. Here, we investigated the function of Rac1 using a membrane recruitment system that mimics phagocytosis. Recruitment of an activated Rac1 protein to the cytoplasmic domain of an engineered membrane receptor by using rapamycin as a bridge induces ingestion of latex beads bound to the receptor. Rac1-mediated bead uptake depends on actin polymerisation since actin filaments accumulate at the bead/membrane binding sites and internalisation is inhibited by cytochalasin D. Internalisation is also abolished upon substitution of Phe37 to Leu in the Rac1 effector region. Our results indicate that by promoting actin polymerisation at particle attachment sites, Rac1 by acting through specific downstream effectors induces plasma membrane remodeling that allows particle internalisation in a membrane-enclosed phagosome." @default.
• W2127810225 created "2016-06-24" @default.
• W2127810225 creator A5003805520 @default.
• W2127810225 creator A5058702473 @default.
• W2127810225 creator A5066969008 @default.
• W2127810225 date "2000-09-01" @default.
• W2127810225 modified "2023-10-18" @default.
• W2127810225 title "Membrane recruitment of Rac1 triggers phagocytosis" @default.
• W2127810225 cites W1520020505 @default.
• W2127810225 cites W1530340727 @default.
• W2127810225 cites W1545383294 @default.
• W2127810225 cites W1969563780 @default.
• W2127810225 cites W1985048358 @default.
• W2127810225 cites W1987005832 @default.
• W2127810225 cites W1992605956 @default.
• W2127810225 cites W1995900983 @default.
• W2127810225 cites W2001234795 @default.
• W2127810225 cites W2002410732 @default.
• W2127810225 cites W2007586038 @default.
• W2127810225 cites W2013592169 @default.
• W2127810225 cites W2023497277 @default.
• W2127810225 cites W2042181517 @default.
• W2127810225 cites W2044732680 @default.
• W2127810225 cites W2045364146 @default.
• W2127810225 cites W2049811440 @default.
• W2127810225 cites W2072837740 @default.
• W2127810225 cites W2073831807 @default.
• W2127810225 cites W2074937633 @default.
• W2127810225 cites W2076586496 @default.
• W2127810225 cites W2077792958 @default.
• W2127810225 cites W2088618181 @default.
• W2127810225 cites W2089626761 @default.
• W2127810225 cites W2090895449 @default.
• W2127810225 cites W2093844155 @default.
• W2127810225 cites W2095139195 @default.
• W2127810225 cites W2104603012 @default.
• W2127810225 cites W2110770741 @default.
• W2127810225 cites W2126233679 @default.
• W2127810225 cites W2147359514 @default.
• W2127810225 cites W2155047359 @default.
• W2127810225 cites W2165607699 @default.
• W2127810225 cites W2167039432 @default.
• W2127810225 cites W2171303172 @default.
• W2127810225 cites W2185722309 @default.
• W2127810225 cites W2279034098 @default.
• W2127810225 doi "https://doi.org/10.1242/jcs.113.17.2955" @default.
• W2127810225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10934035" @default.
• W2127810225 hasPublicationYear "2000" @default.
• W2127810225 type Work @default.
• W2127810225 sameAs 2127810225 @default.
• W2127810225 citedByCount "129" @default.
• W2127810225 countsByYear W21278102252012 @default.
• W2127810225 countsByYear W21278102252013 @default.
• W2127810225 countsByYear W21278102252014 @default.
• W2127810225 countsByYear W21278102252015 @default.
• W2127810225 countsByYear W21278102252016 @default.
• W2127810225 countsByYear W21278102252017 @default.
• W2127810225 countsByYear W21278102252018 @default.
• W2127810225 countsByYear W21278102252019 @default.
• W2127810225 countsByYear W21278102252020 @default.
• W2127810225 countsByYear W21278102252021 @default.
• W2127810225 countsByYear W21278102252022 @default.
• W2127810225 countsByYear W21278102252023 @default.
• W2127810225 crossrefType "journal-article" @default.
• W2127810225 hasAuthorship W2127810225A5003805520 @default.
• W2127810225 hasAuthorship W2127810225A5058702473 @default.
• W2127810225 hasAuthorship W2127810225A5066969008 @default.
• W2127810225 hasConcept C109185818 @default.
• W2127810225 hasConcept C125705527 @default.
• W2127810225 hasConcept C142669718 @default.
• W2127810225 hasConcept C1491633281 @default.
• W2127810225 hasConcept C160448771 @default.
• W2127810225 hasConcept C161478664 @default.
• W2127810225 hasConcept C190062978 @default.
• W2127810225 hasConcept C2776041460 @default.
• W2127810225 hasConcept C2779717556 @default.
• W2127810225 hasConcept C2780040266 @default.
• W2127810225 hasConcept C2993400109 @default.
• W2127810225 hasConcept C38676607 @default.
• W2127810225 hasConcept C55493867 @default.
• W2127810225 hasConcept C62478195 @default.
• W2127810225 hasConcept C86803240 @default.
• W2127810225 hasConcept C95444343 @default.
• W2127810225 hasConceptScore W2127810225C109185818 @default.
• W2127810225 hasConceptScore W2127810225C125705527 @default.
• W2127810225 hasConceptScore W2127810225C142669718 @default.
• W2127810225 hasConceptScore W2127810225C1491633281 @default.
• W2127810225 hasConceptScore W2127810225C160448771 @default.
• W2127810225 hasConceptScore W2127810225C161478664 @default.
• W2127810225 hasConceptScore W2127810225C190062978 @default.
• W2127810225 hasConceptScore W2127810225C2776041460 @default.
• W2127810225 hasConceptScore W2127810225C2779717556 @default.
• W2127810225 hasConceptScore W2127810225C2780040266 @default.
• W2127810225 hasConceptScore W2127810225C2993400109 @default.
• W2127810225 hasConceptScore W2127810225C38676607 @default.
• W2127810225 hasConceptScore W2127810225C55493867 @default.
• W2127810225 hasConceptScore W2127810225C62478195 @default.
• W2127810225 hasConceptScore W2127810225C86803240 @default.

• next