FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127823675> ?p ?o ?g. }

• W2127823675 endingPage "515" @default.
• W2127823675 startingPage "507" @default.
• W2127823675 abstract "Orthopedic wear debris has been thought to be an important factor associated with osteolysis and loosening of total joint arthroplasties. Previous in vitro studies have reported that particles of wear debris induce the release of pro-inflammatory cytokines and other inflammatory mediators from macrophages and other cells. Several recent investigations, however, have suggested that the wear particles themselves may not be primarily responsible for the inflammatory cellular responses, but that the observed cytokine release in vitro may be caused by endotoxin adsorbed to commercially available particle preparations. The intracellular pathways involved in macrophage signal transduction also are poorly understood. The purposes of this study are to use isolated orthopedic wear debris particles to evaluate pro-inflammatory cytokine release and nuclear factor kappa B (NFkappaB) activation from macrophages. Cells from human monocyte/macrophage cell line (THP-1) were differentiated and incubated with particles of debris that had been isolated from a failed human total hip arthroplasty. The titanium-alloy particles did not evoke release of TNF-alpha or IL-1beta whereas lipopolysaccharide (LPS) or LPS-treated debris particles induced both TNF-alpha and IL-1beta. LPS-treated particles, but not particles alone, stimulated NFkappaB activation. Our results suggest that at the concentrations tested in this study, endotoxin-free wear debris particles may not themselves initiate inflammatory cellular responses in differentiated THP-1 cells. It is unclear whether adsorbed endotoxin is clinically associated with osteolysis and/or loosening in total joint arthroplasties, but several factors, including adsorbed endotoxin, need to be investigated to explore the cellular responses responsible for osteolysis and/or loosening." @default.
• W2127823675 created "2016-06-24" @default.
• W2127823675 creator A5019997707 @default.
• W2127823675 creator A5021371159 @default.
• W2127823675 creator A5030942346 @default.
• W2127823675 creator A5065605349 @default.
• W2127823675 date "2001-12-06" @default.
• W2127823675 modified "2023-10-10" @default.
• W2127823675 title "The effect of particle wear debris on NF?B activation and pro-inflammatory cytokine release in differentiated THP-1 cells" @default.
• W2127823675 cites W1493564682 @default.
• W2127823675 cites W1798868335 @default.
• W2127823675 cites W1914858881 @default.
• W2127823675 cites W1920320579 @default.
• W2127823675 cites W1965344276 @default.
• W2127823675 cites W1968750095 @default.
• W2127823675 cites W1970378464 @default.
• W2127823675 cites W1970700880 @default.
• W2127823675 cites W1976862940 @default.
• W2127823675 cites W1983008617 @default.
• W2127823675 cites W1983668987 @default.
• W2127823675 cites W1988320618 @default.
• W2127823675 cites W1993384976 @default.
• W2127823675 cites W2003964180 @default.
• W2127823675 cites W2007835360 @default.
• W2127823675 cites W2030669958 @default.
• W2127823675 cites W2038177927 @default.
• W2127823675 cites W2048967967 @default.
• W2127823675 cites W2053917902 @default.
• W2127823675 cites W2054892084 @default.
• W2127823675 cites W2060942013 @default.
• W2127823675 cites W2065138620 @default.
• W2127823675 cites W2068562565 @default.
• W2127823675 cites W2070875882 @default.
• W2127823675 cites W2073573464 @default.
• W2127823675 cites W2074482911 @default.
• W2127823675 cites W2079060965 @default.
• W2127823675 cites W2096984753 @default.
• W2127823675 cites W2104327830 @default.
• W2127823675 cites W2119569059 @default.
• W2127823675 cites W2126726099 @default.
• W2127823675 cites W2151892297 @default.
• W2127823675 cites W2166781237 @default.
• W2127823675 cites W2228466038 @default.
• W2127823675 cites W2258946399 @default.
• W2127823675 cites W2268968056 @default.
• W2127823675 cites W65922439 @default.
• W2127823675 cites W79229496 @default.
• W2127823675 doi "https://doi.org/10.1002/jbm.1264" @default.
• W2127823675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11774309" @default.
• W2127823675 hasPublicationYear "2001" @default.
• W2127823675 type Work @default.
• W2127823675 sameAs 2127823675 @default.
• W2127823675 citedByCount "82" @default.
• W2127823675 countsByYear W21278236752012 @default.
• W2127823675 countsByYear W21278236752013 @default.
• W2127823675 countsByYear W21278236752014 @default.
• W2127823675 countsByYear W21278236752015 @default.
• W2127823675 countsByYear W21278236752016 @default.
• W2127823675 countsByYear W21278236752017 @default.
• W2127823675 countsByYear W21278236752018 @default.
• W2127823675 countsByYear W21278236752021 @default.
• W2127823675 countsByYear W21278236752023 @default.
• W2127823675 crossrefType "journal-article" @default.
• W2127823675 hasAuthorship W2127823675A5019997707 @default.
• W2127823675 hasAuthorship W2127823675A5021371159 @default.
• W2127823675 hasAuthorship W2127823675A5030942346 @default.
• W2127823675 hasAuthorship W2127823675A5065605349 @default.
• W2127823675 hasConcept C17991360 @default.
• W2127823675 hasConcept C185592680 @default.
• W2127823675 hasConcept C192562407 @default.
• W2127823675 hasConcept C199343813 @default.
• W2127823675 hasConcept C202751555 @default.
• W2127823675 hasConcept C203014093 @default.
• W2127823675 hasConcept C2776914184 @default.
• W2127823675 hasConcept C2778690821 @default.
• W2127823675 hasConcept C2778754761 @default.
• W2127823675 hasConcept C2779244956 @default.
• W2127823675 hasConcept C2781184567 @default.
• W2127823675 hasConcept C2781282405 @default.
• W2127823675 hasConcept C55493867 @default.
• W2127823675 hasConcept C71924100 @default.
• W2127823675 hasConcept C86803240 @default.
• W2127823675 hasConcept C95444343 @default.
• W2127823675 hasConceptScore W2127823675C17991360 @default.
• W2127823675 hasConceptScore W2127823675C185592680 @default.
• W2127823675 hasConceptScore W2127823675C192562407 @default.
• W2127823675 hasConceptScore W2127823675C199343813 @default.
• W2127823675 hasConceptScore W2127823675C202751555 @default.
• W2127823675 hasConceptScore W2127823675C203014093 @default.
• W2127823675 hasConceptScore W2127823675C2776914184 @default.
• W2127823675 hasConceptScore W2127823675C2778690821 @default.
• W2127823675 hasConceptScore W2127823675C2778754761 @default.
• W2127823675 hasConceptScore W2127823675C2779244956 @default.
• W2127823675 hasConceptScore W2127823675C2781184567 @default.
• W2127823675 hasConceptScore W2127823675C2781282405 @default.
• W2127823675 hasConceptScore W2127823675C55493867 @default.
• W2127823675 hasConceptScore W2127823675C71924100 @default.
• W2127823675 hasConceptScore W2127823675C86803240 @default.

• next