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- W2127826425 endingPage "4025" @default.
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- W2127826425 abstract "Sequence analysis of the variable regions of the heavy and light chains of the anti-idiotypic antibody 6F9, which mimics the meningococcal group C capsular polysaccharide (MCP), was performed. The immunogenic site on 6F9 responsible for inducing an anti-MCP antibody response was determined by means of sequence and computer model analysis of these data. Complementarity-determining region 3 (CDR3) was found to be unique in that the sequence tract YRY was exposed on the surface. A synthetic peptide spanning the CDR3 domain was synthesized and complexed to proteosomes (meningococcal group B outer membrane protein). Immunizations of BALB/c mice with the peptide-proteosome complex resulted in a significant anti-MCP antibody response. Immunized mice were protected against infection with a lethal dose of Neisseria meningitidis serogroup C." @default.
- W2127826425 created "2016-06-24" @default.
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- W2127826425 date "1995-04-25" @default.
- W2127826425 modified "2023-09-25" @default.
- W2127826425 title "Peptide mimicry of the meningococcal group C capsular polysaccharide." @default.
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- W2127826425 doi "https://doi.org/10.1073/pnas.92.9.4021" @default.
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