Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127829482> ?p ?o ?g. }
- W2127829482 endingPage "319" @default.
- W2127829482 startingPage "309" @default.
- W2127829482 abstract "The cochleovestibular ganglion of the chick differentiates at early embryonic stages as VIIIth nerve axons enter the brainstem. The tonotopic organization of the auditory portion of the VIIIth nerve can be discerned at the time axons initially reach their brainstem targets. The mechanisms underlying this early organization are not known. Eph receptor tyrosine kinases and their ligands, the ephrins, have a demonstrated role in guiding axons to topographically appropriate locations in other areas of the nervous system. In order to begin to test whether Eph proteins have a similar role in the auditory system, we investigated the tonotopic expression of several Eph receptors and ephrins in the VIIIth nerve during embryonic ages corresponding to the initial innervation of the auditory brainstem. Expression patterns of EphA4, EphB2, EphB5, ephrin-A2, and ephrin-B1 were evaluated immunohistochemically at embryonic days 4 through 10. Protein expression was observed in the cochlear ganglion and VIIIth nerve axons at these ages. EphB5, ephrin-A2, and ephrin-B1 were expressed throughout the nerve. EphA4 and EphB2 had complementary expression patterns within the nerve, with EphA4 expression higher in the dorsolateral part of the nerve and EphB2 expression higher in the ventromedial part of the nerve. These regions may correspond to auditory and vestibular components, respectively. Moreover, EphA4 expression was higher toward the low-frequency region of both the centrally and peripherally projecting branches of cochlear ganglion cells. Regional variation of Eph protein expression may influence the target selection and topography of developing VIIIth nerve projections." @default.
- W2127829482 created "2016-06-24" @default.
- W2127829482 creator A5017625586 @default.
- W2127829482 creator A5083324841 @default.
- W2127829482 date "2005-01-24" @default.
- W2127829482 modified "2023-10-14" @default.
- W2127829482 title "Differential expression of Eph receptors and ephrins in the cochlear ganglion and eighth cranial nerve of the chick embryo" @default.
- W2127829482 cites W1501558564 @default.
- W2127829482 cites W1503857273 @default.
- W2127829482 cites W1555506001 @default.
- W2127829482 cites W1674091940 @default.
- W2127829482 cites W192776057 @default.
- W2127829482 cites W1931479270 @default.
- W2127829482 cites W1964435709 @default.
- W2127829482 cites W1973200223 @default.
- W2127829482 cites W1973881587 @default.
- W2127829482 cites W1976867481 @default.
- W2127829482 cites W1977393834 @default.
- W2127829482 cites W1977413405 @default.
- W2127829482 cites W1977455576 @default.
- W2127829482 cites W1978936588 @default.
- W2127829482 cites W1984755886 @default.
- W2127829482 cites W1986778708 @default.
- W2127829482 cites W1997946018 @default.
- W2127829482 cites W1998255137 @default.
- W2127829482 cites W1999747077 @default.
- W2127829482 cites W2013348327 @default.
- W2127829482 cites W2013667500 @default.
- W2127829482 cites W2015863739 @default.
- W2127829482 cites W2016567075 @default.
- W2127829482 cites W2016977025 @default.
- W2127829482 cites W2023381747 @default.
- W2127829482 cites W2032276260 @default.
- W2127829482 cites W2034841185 @default.
- W2127829482 cites W2036515774 @default.
- W2127829482 cites W2037641677 @default.
- W2127829482 cites W2038894508 @default.
- W2127829482 cites W2042482088 @default.
- W2127829482 cites W2042902655 @default.
- W2127829482 cites W2043007476 @default.
- W2127829482 cites W2043562994 @default.
- W2127829482 cites W2048160623 @default.
- W2127829482 cites W2048189081 @default.
- W2127829482 cites W2051822811 @default.
- W2127829482 cites W2053119705 @default.
- W2127829482 cites W2056745170 @default.
- W2127829482 cites W2066500575 @default.
- W2127829482 cites W2073719363 @default.
- W2127829482 cites W2074345277 @default.
- W2127829482 cites W2078885383 @default.
- W2127829482 cites W2082581761 @default.
- W2127829482 cites W2093436655 @default.
- W2127829482 cites W2093605386 @default.
- W2127829482 cites W2098554273 @default.
- W2127829482 cites W2098565860 @default.
- W2127829482 cites W2101168877 @default.
- W2127829482 cites W2102270872 @default.
- W2127829482 cites W2106165942 @default.
- W2127829482 cites W2108613636 @default.
- W2127829482 cites W2109664676 @default.
- W2127829482 cites W2112630884 @default.
- W2127829482 cites W2114309709 @default.
- W2127829482 cites W2120446671 @default.
- W2127829482 cites W2120760119 @default.
- W2127829482 cites W2121227011 @default.
- W2127829482 cites W2128556377 @default.
- W2127829482 cites W2138475086 @default.
- W2127829482 cites W2142190178 @default.
- W2127829482 cites W2143076872 @default.
- W2127829482 cites W2144098111 @default.
- W2127829482 cites W2147354064 @default.
- W2127829482 cites W2159581330 @default.
- W2127829482 cites W2160979115 @default.
- W2127829482 cites W2161022070 @default.
- W2127829482 cites W2162534020 @default.
- W2127829482 cites W2169499901 @default.
- W2127829482 cites W2170562570 @default.
- W2127829482 cites W2346864743 @default.
- W2127829482 cites W4229680502 @default.
- W2127829482 cites W79238280 @default.
- W2127829482 doi "https://doi.org/10.1002/cne.20396" @default.
- W2127829482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15669077" @default.
- W2127829482 hasPublicationYear "2005" @default.
- W2127829482 type Work @default.
- W2127829482 sameAs 2127829482 @default.
- W2127829482 citedByCount "27" @default.
- W2127829482 countsByYear W21278294822012 @default.
- W2127829482 countsByYear W21278294822013 @default.
- W2127829482 countsByYear W21278294822014 @default.
- W2127829482 countsByYear W21278294822015 @default.
- W2127829482 countsByYear W21278294822017 @default.
- W2127829482 countsByYear W21278294822021 @default.
- W2127829482 countsByYear W21278294822022 @default.
- W2127829482 crossrefType "journal-article" @default.
- W2127829482 hasAuthorship W2127829482A5017625586 @default.
- W2127829482 hasAuthorship W2127829482A5083324841 @default.
- W2127829482 hasConcept C101544691 @default.
- W2127829482 hasConcept C105702510 @default.