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• W2127865713 abstract "Four phases (0 to 3) were defined kinetically for potassium in the dog papillary muscle when perfused arterially for four to five hours with solution containing 4 mM/liter K + . Total tissue K + fell from 91.1±1.99 to 41.0±1.06 mmoles/liter after three hours perfusion. It then remained stable during the period when kinetic studies were done. The mean rate constant λ (min -1 ), potassium content (mmoles/liter tissue water) and suggested origin of each phase are respectively: (phase 0) λ 0 = 3.2, 0.3, vascular; (phase 1) λ 1 = 0.65, 2.06, interstitial; (phase 2) λ 2 = 0.0139, 39.3, intracellular; (phase 3) λ 3 < 0.004, <0.5, origin unknown. Alteration of K + concentration in perfusing fluid produced significant changes in the intracellular exchange rate of K + . This was in marked contrast to increments in frequency of contraction which had no effect on the overall exchangeability of intracellular potassium. Increases in rate, however, were associated with a transient net loss of intracellular K + . This loss continued if the active tension of the muscle declined and if contracture progressed. The loss ceased if muscle function remained stable during continued increased frequency of contraction. A positive tension staircase was approximately proportional to the net K + loss. The net K + loss was 0.93 mmole/liter tissue water in nine muscles in which a mean 27 beats/min rate increment was introduced for a mean of 16 minutes. This represented 2.4% of intracellular K + . A significant time lag was found before the net K + loss reached a maximum rate and began to decline. This is compared with the previously demonstrated transient net increment in Ca ++ uptake that accompanies increased frequency of contraction. These ionic movements are consistent with the theory that Na + movements in and out of a specialized membrane region are related to Ca ++ movements and thereby influence the control of myocardial contractility." @default.
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• W2127865713 date "1966-02-01" @default.
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• W2127865713 title "Potassium in Dog Ventricular Muscle: Kinetic Studies of Distribution and Effects of Varying Frequency of Contraction and Potassium Concentration of Perfusate" @default.
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• W2127865713 doi "https://doi.org/10.1161/01.res.18.2.164" @default.
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