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• W2127876468 abstract "Contrary to high expectations, the majority of clinically approved anti-cancer nanomedicine, and those under clinical trials, have shown limited therapeutic efficacy in humans. So, why these nanomedicine are not delivering their promise? Here, we discuss likely factors, and call for a paradigm shift in approach and design of future cancer nanotherapeutics based on realistic cancer models representing human disease, and better understanding of integrated pathophysiological processes, including systems immunology, that modulate human tumor functionality and growth. This critical review of the current state of translational oncology research utilizing nanomedicine-based approaches provides a comprehensive discussion of the multiple factors that are responsible for poor outcomes when translating these approaches models to the actual human disease." @default.
• W2127876468 created "2016-06-24" @default.
• W2127876468 creator A5005034103 @default.
• W2127876468 creator A5078365658 @default.
• W2127876468 date "2014-11-01" @default.
• W2127876468 modified "2023-10-11" @default.
• W2127876468 title "Just so stories: The random acts of anti-cancer nanomedicine performance" @default.
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• W2127876468 doi "https://doi.org/10.1016/j.nano.2014.04.011" @default.
• W2127876468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24832960" @default.
• W2127876468 hasPublicationYear "2014" @default.
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