FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127931049> ?p ?o ?g. }

• W2127931049 endingPage "22" @default.
• W2127931049 startingPage "9" @default.
• W2127931049 abstract "The pentacyclic acridinium salt RHPS4 displays anti-tumour properties in vitro as well as in vivo and is potentially cell-cycle specific. We have collected experimental data and formulated a compartmental model using ordinary differential equations to investigate how the compound affects cells in each stage of the cell cycle. In addition to a control case in which no drug was used, we treated colorectal cancer cells with three different concentrations of the drug and fitted simulations from our models to experimental observations. We found that RHPS4 caused a concentration-dependent, marked cell death in treated cells, which is best modelled by allowing the rate parameters corresponding to cell death to be sigmoidal functions of time. We have shown that the model is identifiable, meaning that, at least in principle, the parameter values can be determined from observable quantities. We find that at low concentrations RHPS4 primarily affects the cells in the G(2)/M phase, and that the drug has a delayed effect with the delay decreasing at larger doses. Since the drug diffuses into the nucleus, the observed delayed effect of the compound is unexpected and is a novel finding of our research into this compound." @default.
• W2127931049 created "2016-06-24" @default.
• W2127931049 creator A5041172026 @default.
• W2127931049 creator A5057748100 @default.
• W2127931049 creator A5064083972 @default.
• W2127931049 creator A5072475607 @default.
• W2127931049 date "2012-02-01" @default.
• W2127931049 modified "2023-09-23" @default.
• W2127931049 title "The effects of a telomere destabilizing agent on cancer cell-cycle dynamics—Integrated modelling and experiments" @default.
• W2127931049 cites W1501949263 @default.
• W2127931049 cites W151714794 @default.
• W2127931049 cites W1878726100 @default.
• W2127931049 cites W1881146567 @default.
• W2127931049 cites W1975028780 @default.
• W2127931049 cites W1982861164 @default.
• W2127931049 cites W1993469796 @default.
• W2127931049 cites W1996195324 @default.
• W2127931049 cites W2000971601 @default.
• W2127931049 cites W2025483504 @default.
• W2127931049 cites W2026370504 @default.
• W2127931049 cites W2027662951 @default.
• W2127931049 cites W2028345897 @default.
• W2127931049 cites W2028412780 @default.
• W2127931049 cites W2029987088 @default.
• W2127931049 cites W2031421725 @default.
• W2127931049 cites W2031888565 @default.
• W2127931049 cites W2032475797 @default.
• W2127931049 cites W2042982699 @default.
• W2127931049 cites W2043564369 @default.
• W2127931049 cites W2059238994 @default.
• W2127931049 cites W2063148361 @default.
• W2127931049 cites W2067038367 @default.
• W2127931049 cites W2069353545 @default.
• W2127931049 cites W2078786713 @default.
• W2127931049 cites W2081654665 @default.
• W2127931049 cites W2083311145 @default.
• W2127931049 cites W2083550700 @default.
• W2127931049 cites W2085967779 @default.
• W2127931049 cites W2086056969 @default.
• W2127931049 cites W2098229509 @default.
• W2127931049 cites W2101288870 @default.
• W2127931049 cites W2105759091 @default.
• W2127931049 cites W2118646042 @default.
• W2127931049 cites W2119571991 @default.
• W2127931049 cites W2122935835 @default.
• W2127931049 cites W2132415951 @default.
• W2127931049 cites W2142635246 @default.
• W2127931049 cites W2150042165 @default.
• W2127931049 cites W2151339633 @default.
• W2127931049 cites W2157378162 @default.
• W2127931049 cites W2168700995 @default.
• W2127931049 cites W2264709743 @default.
• W2127931049 cites W2332695057 @default.
• W2127931049 cites W2489605225 @default.
• W2127931049 cites W2987025408 @default.
• W2127931049 cites W2064142190 @default.
• W2127931049 doi "https://doi.org/10.1016/j.jtbi.2011.10.038" @default.
• W2127931049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22108242" @default.
• W2127931049 hasPublicationYear "2012" @default.
• W2127931049 type Work @default.
• W2127931049 sameAs 2127931049 @default.
• W2127931049 citedByCount "3" @default.
• W2127931049 countsByYear W21279310492012 @default.
• W2127931049 countsByYear W21279310492013 @default.
• W2127931049 countsByYear W21279310492017 @default.
• W2127931049 crossrefType "journal-article" @default.
• W2127931049 hasAuthorship W2127931049A5041172026 @default.
• W2127931049 hasAuthorship W2127931049A5057748100 @default.
• W2127931049 hasAuthorship W2127931049A5064083972 @default.
• W2127931049 hasAuthorship W2127931049A5072475607 @default.
• W2127931049 hasBestOaLocation W21279310491 @default.
• W2127931049 hasConcept C121332964 @default.
• W2127931049 hasConcept C121608353 @default.
• W2127931049 hasConcept C12554922 @default.
• W2127931049 hasConcept C134306372 @default.
• W2127931049 hasConcept C1491633281 @default.
• W2127931049 hasConcept C177336024 @default.
• W2127931049 hasConcept C185592680 @default.
• W2127931049 hasConcept C186060115 @default.
• W2127931049 hasConcept C202751555 @default.
• W2127931049 hasConcept C207001950 @default.
• W2127931049 hasConcept C2780035454 @default.
• W2127931049 hasConcept C29537977 @default.
• W2127931049 hasConcept C32848918 @default.
• W2127931049 hasConcept C33923547 @default.
• W2127931049 hasConcept C51544822 @default.
• W2127931049 hasConcept C54355233 @default.
• W2127931049 hasConcept C552990157 @default.
• W2127931049 hasConcept C55493867 @default.
• W2127931049 hasConcept C62520636 @default.
• W2127931049 hasConcept C78045399 @default.
• W2127931049 hasConcept C86803240 @default.
• W2127931049 hasConcept C96232424 @default.
• W2127931049 hasConcept C98274493 @default.
• W2127931049 hasConceptScore W2127931049C121332964 @default.
• W2127931049 hasConceptScore W2127931049C121608353 @default.
• W2127931049 hasConceptScore W2127931049C12554922 @default.
• W2127931049 hasConceptScore W2127931049C134306372 @default.

• next