FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127940865> ?p ?o ?g. }

• W2127940865 endingPage "1359" @default.
• W2127940865 startingPage "1351" @default.
• W2127940865 abstract "Abstract Tumor-targeted vaccines represent a strategy to enhance the graft-versus-leukemia effect after allogeneic blood and marrow transplantation (BMT). We have previously shown that graft-versus-host disease (GVHD) can negatively impact quantitative responses to vaccines. Using a minor histocompatibility Ag–mismatched BMT (B6→B6 × C3H.SW) followed by adoptive transfer of HY-specific T cells and HY-expressing dendritic cells, we assessed whether GVHD induced by donor lymphocyte infusion (DLI) affects the persistence, proliferation, and survival of vaccine-responding, nonalloantigen reactive T cells. Both CD8+ and CD4+ HY-specific T cells undergo less vaccine-driven proliferation in allogeneic recipients with GVHD. Although vaccine-responding CD8+ T cells show decreased IFN-γ and CD107a production, CD4+ T cells exhibit increased programmed death 1 and T cell Ig mucin-like domain 3 expression. In addition, the degree of apoptosis in vaccine-responding CD8+ T cells was higher in the presence of GVHD, but there was no difference in CD4+ T cell apoptosis. Using Fas ligand–deficient or TRAIL-deficient DLI had no impact on apoptosis of HY-specific T cells. However, perforin-deficient alloreactive DLI induced significantly less apoptosis of vaccine-responding CD8+ T cells and resulted in enhanced tumor protection. Thus, diminished vaccine responses during GVHD result from impaired proliferation of CD8+ and CD4+ T cells responding to vaccination, with an additional contribution from perforin-mediated CD8+ T cell apoptosis. These results provide important insights toward optimizing vaccine responses after allogeneic BMT." @default.
• W2127940865 created "2016-06-24" @default.
• W2127940865 creator A5011524529 @default.
• W2127940865 creator A5017207916 @default.
• W2127940865 creator A5025108971 @default.
• W2127940865 creator A5054397260 @default.
• W2127940865 creator A5084508530 @default.
• W2127940865 date "2013-02-01" @default.
• W2127940865 modified "2023-10-03" @default.
• W2127940865 title "Graft-versus-Host Disease Impairs Vaccine Responses through Decreased CD4+ and CD8+ T Cell Proliferation and Increased Perforin-Mediated CD8+ T Cell Apoptosis" @default.
• W2127940865 cites W1496164131 @default.
• W2127940865 cites W1521515468 @default.
• W2127940865 cites W1526571057 @default.
• W2127940865 cites W156080801 @default.
• W2127940865 cites W1572649987 @default.
• W2127940865 cites W158630194 @default.
• W2127940865 cites W1594653361 @default.
• W2127940865 cites W1630218117 @default.
• W2127940865 cites W1973703163 @default.
• W2127940865 cites W1987754685 @default.
• W2127940865 cites W1991344211 @default.
• W2127940865 cites W2006703121 @default.
• W2127940865 cites W2018512108 @default.
• W2127940865 cites W2020663791 @default.
• W2127940865 cites W2027456984 @default.
• W2127940865 cites W2036735368 @default.
• W2127940865 cites W2040870229 @default.
• W2127940865 cites W2050899268 @default.
• W2127940865 cites W2053402248 @default.
• W2127940865 cites W2054637226 @default.
• W2127940865 cites W2054702356 @default.
• W2127940865 cites W2054741506 @default.
• W2127940865 cites W2062354024 @default.
• W2127940865 cites W2063236939 @default.
• W2127940865 cites W2069467162 @default.
• W2127940865 cites W2071732845 @default.
• W2127940865 cites W2071871975 @default.
• W2127940865 cites W2076597201 @default.
• W2127940865 cites W2088895543 @default.
• W2127940865 cites W2113687524 @default.
• W2127940865 cites W2139870920 @default.
• W2127940865 cites W2144530070 @default.
• W2127940865 cites W2144578446 @default.
• W2127940865 cites W2148661343 @default.
• W2127940865 cites W2154852058 @default.
• W2127940865 cites W2168987586 @default.
• W2127940865 cites W2236858314 @default.
• W2127940865 cites W2319987395 @default.
• W2127940865 cites W4231600099 @default.
• W2127940865 cites W4242667310 @default.
• W2127940865 cites W4248809108 @default.
• W2127940865 cites W4313333754 @default.
• W2127940865 doi "https://doi.org/10.4049/jimmunol.1200391" @default.
• W2127940865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3626171" @default.
• W2127940865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23275602" @default.
• W2127940865 hasPublicationYear "2013" @default.
• W2127940865 type Work @default.
• W2127940865 sameAs 2127940865 @default.
• W2127940865 citedByCount "14" @default.
• W2127940865 countsByYear W21279408652013 @default.
• W2127940865 countsByYear W21279408652014 @default.
• W2127940865 countsByYear W21279408652015 @default.
• W2127940865 countsByYear W21279408652016 @default.
• W2127940865 countsByYear W21279408652017 @default.
• W2127940865 countsByYear W21279408652018 @default.
• W2127940865 countsByYear W21279408652020 @default.
• W2127940865 countsByYear W21279408652021 @default.
• W2127940865 countsByYear W21279408652023 @default.
• W2127940865 crossrefType "journal-article" @default.
• W2127940865 hasAuthorship W2127940865A5011524529 @default.
• W2127940865 hasAuthorship W2127940865A5017207916 @default.
• W2127940865 hasAuthorship W2127940865A5025108971 @default.
• W2127940865 hasAuthorship W2127940865A5054397260 @default.
• W2127940865 hasAuthorship W2127940865A5084508530 @default.
• W2127940865 hasBestOaLocation W21279408651 @default.
• W2127940865 hasConcept C154317977 @default.
• W2127940865 hasConcept C167672396 @default.
• W2127940865 hasConcept C190283241 @default.
• W2127940865 hasConcept C202751555 @default.
• W2127940865 hasConcept C203014093 @default.
• W2127940865 hasConcept C2776062744 @default.
• W2127940865 hasConcept C2776090121 @default.
• W2127940865 hasConcept C2779972918 @default.
• W2127940865 hasConcept C28328180 @default.
• W2127940865 hasConcept C502942594 @default.
• W2127940865 hasConcept C55493867 @default.
• W2127940865 hasConcept C86803240 @default.
• W2127940865 hasConcept C8891405 @default.
• W2127940865 hasConcept C90375314 @default.
• W2127940865 hasConcept C95444343 @default.
• W2127940865 hasConceptScore W2127940865C154317977 @default.
• W2127940865 hasConceptScore W2127940865C167672396 @default.
• W2127940865 hasConceptScore W2127940865C190283241 @default.
• W2127940865 hasConceptScore W2127940865C202751555 @default.
• W2127940865 hasConceptScore W2127940865C203014093 @default.
• W2127940865 hasConceptScore W2127940865C2776062744 @default.
• W2127940865 hasConceptScore W2127940865C2776090121 @default.
• W2127940865 hasConceptScore W2127940865C2779972918 @default.

• next