FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127979283> ?p ?o ?g. }

• W2127979283 endingPage "7042" @default.
• W2127979283 startingPage "7029" @default.
• W2127979283 abstract "RecG and RuvAB are proposed to act at stalled DNA replication forks to facilitate replication restart. To define the roles of these proteins in fork regression, we used a combination of assays to determine whether RecG, RuvAB or both are capable of acting at a stalled fork. The results show that RecG binds to the C-terminus of single-stranded DNA binding protein (SSB) forming a stoichiometric complex of 2 RecG monomers per SSB tetramer. This binding occurs in solution and to SSB protein bound to single stranded DNA (ssDNA). The result of this binding is stabilization of the interaction of RecG with ssDNA. In contrast, RuvAB does not bind to SSB. Side-by-side analysis of the catalytic efficiency of the ATPase activity of each enzyme revealed that (-)scDNA and ssDNA are potent stimulators of the ATPase activity of RecG but not for RuvAB, whereas relaxed circular DNA is a poor cofactor for RecG but an excellent one for RuvAB. Collectively, these data suggest that the timing of repair protein access to the DNA at stalled forks is determined by the nature of the DNA available at the fork. We propose that RecG acts first, with RuvAB acting either after RecG or in a separate pathway following protein-independent fork regression." @default.
• W2127979283 created "2016-06-24" @default.
• W2127979283 creator A5036019614 @default.
• W2127979283 creator A5060644426 @default.
• W2127979283 creator A5060925000 @default.
• W2127979283 date "2008-11-05" @default.
• W2127979283 modified "2023-09-25" @default.
• W2127979283 title "RecG interacts directly with SSB: implications for stalled replication fork regression" @default.
• W2127979283 cites W1481855462 @default.
• W2127979283 cites W1511229070 @default.
• W2127979283 cites W1512528596 @default.
• W2127979283 cites W1518548089 @default.
• W2127979283 cites W1521689319 @default.
• W2127979283 cites W1523754606 @default.
• W2127979283 cites W1543741267 @default.
• W2127979283 cites W1559132509 @default.
• W2127979283 cites W1570361288 @default.
• W2127979283 cites W1597020672 @default.
• W2127979283 cites W1885726311 @default.
• W2127979283 cites W1965780315 @default.
• W2127979283 cites W1967215948 @default.
• W2127979283 cites W1974103615 @default.
• W2127979283 cites W1981829426 @default.
• W2127979283 cites W1987914894 @default.
• W2127979283 cites W1998772598 @default.
• W2127979283 cites W1998885699 @default.
• W2127979283 cites W2001167026 @default.
• W2127979283 cites W2005986251 @default.
• W2127979283 cites W2014570065 @default.
• W2127979283 cites W2015366670 @default.
• W2127979283 cites W2015830185 @default.
• W2127979283 cites W2018721796 @default.
• W2127979283 cites W2018858256 @default.
• W2127979283 cites W2019146077 @default.
• W2127979283 cites W2024768124 @default.
• W2127979283 cites W2024922257 @default.
• W2127979283 cites W2038093678 @default.
• W2127979283 cites W2039751418 @default.
• W2127979283 cites W2039764581 @default.
• W2127979283 cites W2045090331 @default.
• W2127979283 cites W2048680704 @default.
• W2127979283 cites W2050149166 @default.
• W2127979283 cites W2050150719 @default.
• W2127979283 cites W2051058497 @default.
• W2127979283 cites W2051530487 @default.
• W2127979283 cites W2052738967 @default.
• W2127979283 cites W2056884132 @default.
• W2127979283 cites W2063188563 @default.
• W2127979283 cites W2065146563 @default.
• W2127979283 cites W2066427226 @default.
• W2127979283 cites W2066638568 @default.
• W2127979283 cites W2071662270 @default.
• W2127979283 cites W2072879515 @default.
• W2127979283 cites W2076942358 @default.
• W2127979283 cites W2077535486 @default.
• W2127979283 cites W2079862891 @default.
• W2127979283 cites W2081669092 @default.
• W2127979283 cites W2084158547 @default.
• W2127979283 cites W2089647775 @default.
• W2127979283 cites W2097507625 @default.
• W2127979283 cites W2100489858 @default.
• W2127979283 cites W2103170383 @default.
• W2127979283 cites W2105444563 @default.
• W2127979283 cites W2108660167 @default.
• W2127979283 cites W2109339776 @default.
• W2127979283 cites W2114809602 @default.
• W2127979283 cites W2114965792 @default.
• W2127979283 cites W2118504920 @default.
• W2127979283 cites W2119862706 @default.
• W2127979283 cites W2121942815 @default.
• W2127979283 cites W2122531070 @default.
• W2127979283 cites W2132953534 @default.
• W2127979283 cites W2133279612 @default.
• W2127979283 cites W2133290100 @default.
• W2127979283 cites W2135128865 @default.
• W2127979283 cites W2139925979 @default.
• W2127979283 cites W2145304961 @default.
• W2127979283 cites W2147220402 @default.
• W2127979283 cites W2155934335 @default.
• W2127979283 cites W2158815846 @default.
• W2127979283 cites W2163659193 @default.
• W2127979283 cites W2167342214 @default.
• W2127979283 cites W2168839178 @default.
• W2127979283 cites W2171333363 @default.
• W2127979283 cites W4242223940 @default.
• W2127979283 doi "https://doi.org/10.1093/nar/gkn795" @default.
• W2127979283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2602778" @default.
• W2127979283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18986999" @default.
• W2127979283 hasPublicationYear "2008" @default.
• W2127979283 type Work @default.
• W2127979283 sameAs 2127979283 @default.
• W2127979283 citedByCount "83" @default.
• W2127979283 countsByYear W21279792832012 @default.
• W2127979283 countsByYear W21279792832013 @default.
• W2127979283 countsByYear W21279792832014 @default.
• W2127979283 countsByYear W21279792832015 @default.
• W2127979283 countsByYear W21279792832016 @default.
• W2127979283 countsByYear W21279792832017 @default.

• next