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- W2127987668 endingPage "R64" @default.
- W2127987668 startingPage "R49" @default.
- W2127987668 abstract "Prostate cancer (PCa) is one of the most common causes of male cancer-related death in Western nations. The cellular response to androgens is mediated via the androgen receptor (AR), a ligand-inducible transcription factor whose dysregulation plays a key role during PCa development and progression following androgen deprivation therapy, the current mainstay systemic treatment for advanced PCa. Thus, a better understanding of AR signaling and new strategies to abrogate AR activity are essential for improved therapeutic intervention. Consequently, a large number of experimental cell culture models have been established to facilitate in vitro investigations into the role of AR signaling in PCa development and progression. These different model systems mimic distinct stages of this heterogeneous disease and exhibit differences with respect to AR expression/status and androgen responsiveness. Technological advances have facilitated the development of in vitro systems that more closely reflect the physiological setting, for example via the use of three-dimensional coculture to study the interaction of prostate epithelial cells with the stroma, endothelium, immune system and tissue matrix environment. This review provides an overview of the most commonly used in vitro cell models currently available to study AR signaling with particular focus on their use in addressing key questions relating to the development and progression of PCa. It is hoped that the continued development of in vitro models will provide more biologically relevant platforms for mechanistic studies, drug discovery and design ensuring a more rapid transfer of knowledge from the laboratory to the clinic." @default.
- W2127987668 created "2016-06-24" @default.
- W2127987668 creator A5008951210 @default.
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- W2127987668 creator A5067705347 @default.
- W2127987668 creator A5082650526 @default.
- W2127987668 creator A5085915963 @default.
- W2127987668 date "2013-02-27" @default.
- W2127987668 modified "2023-10-16" @default.
- W2127987668 title "In vitro model systems to study androgen receptor signaling in prostate cancer" @default.
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