FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127998753> ?p ?o ?g. }

• W2127998753 endingPage "e61805" @default.
• W2127998753 startingPage "e61805" @default.
• W2127998753 abstract "Myopia is the most common ocular disease worldwide. We investigated the association of high myopia with the common single nucleotide polymorphisms (SNPs) of five candidate genes - early growth response 1 (EGR1), v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS), jun oncogene (JUN), vasoactive intestinal peptide (VIP), and vasoactive intestinal peptide receptor 2 (VIPR2). We recruited 1200 unrelated Chinese subjects with 600 cases (spherical equivalent ≤-8.00 diopters) and 600 controls (spherical equivalent within ±1.00 diopter). A discovery sample set was formed from 300 cases and 300 controls, and a replication sample set from the remaining samples. Tag SNPs were genotyped for the discovery sample set, and the most significant haplotypes and their constituent SNPs were followed up with the replication sample set. The allele and haplotype frequencies in cases and controls were compared by logistic regression adjusted for sex and age to give P a values, and multiple comparisons were corrected by permutation test to give P aemp values. Odd ratios (OR) were calculated accordingly. In the discovery phase, EGR1, JUN and VIP did not show any significant association while FOS and VIPR2 demonstrated significant haplotype association with high myopia. In the replication phase, the haplotype association for VIPR2 was successfully replicated, but not FOS. In analysis combining both sample sets, the most significant association signals of VIPR2 were the single marker rs2071625 (P a = 0.0008, P aemp = 0.0046 and OR = 0.75) and the 4-SNP haplotype window rs2071623-rs2071625-rs2730220-rs885863 (omnibus test, P a = 9.10e-10 and P aemp = 0.0001) with one protective haplotype (GGGG: P aemp = 0.0002 and OR = 0.52) and one high-risk haplotype (GAGA: P aemp = 0.0027 and OR = 4.68). This 4-SNP haplotype window was the most significant in all sample sets examined. This is the first study to suggest a role of VIPR2 in the genetic susceptibility to high myopia. EGR1, JUN, FOS and VIP are unlikely to be important in predisposing humans to high myopia." @default.
• W2127998753 created "2016-06-24" @default.
• W2127998753 creator A5005600019 @default.
• W2127998753 creator A5065779339 @default.
• W2127998753 creator A5081812552 @default.
• W2127998753 creator A5084019477 @default.
• W2127998753 creator A5087757804 @default.
• W2127998753 date "2013-04-18" @default.
• W2127998753 modified "2023-10-03" @default.
• W2127998753 title "Genetic Susceptibility to Refractive Error: Association of Vasoactive Intestinal Peptide Receptor 2 (VIPR2) with High Myopia in Chinese" @default.
• W2127998753 cites W1568943792 @default.
• W2127998753 cites W1579540011 @default.
• W2127998753 cites W1971855649 @default.
• W2127998753 cites W1971959365 @default.
• W2127998753 cites W1973057408 @default.
• W2127998753 cites W1985351641 @default.
• W2127998753 cites W1985449691 @default.
• W2127998753 cites W1989147684 @default.
• W2127998753 cites W1992985671 @default.
• W2127998753 cites W1996121046 @default.
• W2127998753 cites W1996215908 @default.
• W2127998753 cites W2007429410 @default.
• W2127998753 cites W2013773891 @default.
• W2127998753 cites W2025044344 @default.
• W2127998753 cites W2036758779 @default.
• W2127998753 cites W2039452535 @default.
• W2127998753 cites W2045973968 @default.
• W2127998753 cites W2050656329 @default.
• W2127998753 cites W2068510973 @default.
• W2127998753 cites W2071226610 @default.
• W2127998753 cites W2074709231 @default.
• W2127998753 cites W2081872599 @default.
• W2127998753 cites W2087533466 @default.
• W2127998753 cites W2096882849 @default.
• W2127998753 cites W2107500120 @default.
• W2127998753 cites W2114419737 @default.
• W2127998753 cites W2125538232 @default.
• W2127998753 cites W2125814043 @default.
• W2127998753 cites W2133763585 @default.
• W2127998753 cites W2141265124 @default.
• W2127998753 cites W2143992683 @default.
• W2127998753 cites W2156247496 @default.
• W2127998753 cites W2161633633 @default.
• W2127998753 cites W2162530578 @default.
• W2127998753 cites W2165598939 @default.
• W2127998753 cites W2168579036 @default.
• W2127998753 cites W2169120674 @default.
• W2127998753 cites W2170786019 @default.
• W2127998753 cites W2170959062 @default.
• W2127998753 cites W2171179585 @default.
• W2127998753 cites W2293379200 @default.
• W2127998753 doi "https://doi.org/10.1371/journal.pone.0061805" @default.
• W2127998753 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3630195" @default.
• W2127998753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23637909" @default.
• W2127998753 hasPublicationYear "2013" @default.
• W2127998753 type Work @default.
• W2127998753 sameAs 2127998753 @default.
• W2127998753 citedByCount "20" @default.
• W2127998753 countsByYear W21279987532014 @default.
• W2127998753 countsByYear W21279987532015 @default.
• W2127998753 countsByYear W21279987532016 @default.
• W2127998753 countsByYear W21279987532017 @default.
• W2127998753 countsByYear W21279987532018 @default.
• W2127998753 countsByYear W21279987532019 @default.
• W2127998753 countsByYear W21279987532020 @default.
• W2127998753 countsByYear W21279987532021 @default.
• W2127998753 countsByYear W21279987532022 @default.
• W2127998753 countsByYear W21279987532023 @default.
• W2127998753 crossrefType "journal-article" @default.
• W2127998753 hasAuthorship W2127998753A5005600019 @default.
• W2127998753 hasAuthorship W2127998753A5065779339 @default.
• W2127998753 hasAuthorship W2127998753A5081812552 @default.
• W2127998753 hasAuthorship W2127998753A5084019477 @default.
• W2127998753 hasAuthorship W2127998753A5087757804 @default.
• W2127998753 hasBestOaLocation W21279987531 @default.
• W2127998753 hasConcept C104317684 @default.
• W2127998753 hasConcept C118303440 @default.
• W2127998753 hasConcept C126322002 @default.
• W2127998753 hasConcept C135763542 @default.
• W2127998753 hasConcept C139275648 @default.
• W2127998753 hasConcept C153209595 @default.
• W2127998753 hasConcept C156957248 @default.
• W2127998753 hasConcept C170493617 @default.
• W2127998753 hasConcept C180754005 @default.
• W2127998753 hasConcept C197754878 @default.
• W2127998753 hasConcept C54355233 @default.
• W2127998753 hasConcept C71924100 @default.
• W2127998753 hasConcept C8330315 @default.
• W2127998753 hasConcept C86803240 @default.
• W2127998753 hasConceptScore W2127998753C104317684 @default.
• W2127998753 hasConceptScore W2127998753C118303440 @default.
• W2127998753 hasConceptScore W2127998753C126322002 @default.
• W2127998753 hasConceptScore W2127998753C135763542 @default.
• W2127998753 hasConceptScore W2127998753C139275648 @default.
• W2127998753 hasConceptScore W2127998753C153209595 @default.
• W2127998753 hasConceptScore W2127998753C156957248 @default.
• W2127998753 hasConceptScore W2127998753C170493617 @default.
• W2127998753 hasConceptScore W2127998753C180754005 @default.

• next