Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128003472> ?p ?o ?g. }
- W2128003472 endingPage "751" @default.
- W2128003472 startingPage "742" @default.
- W2128003472 abstract "Thyroid hormones influence both neuronal development and anxiety via the thyroid hormone receptors (TRs). The TRs are encoded by two different genes, TRα and TRβ. The loss of TRα1 is implicated in increased anxiety in males, possibly via a hippocampal increase in GABAergic activity. We compared both social behaviors and two underlying and related non-social behaviors, state anxiety and responses to acoustic and tactile startle in the gonadally intact TRα1 knockout (α1KO) and TRβ (βKO) male mice to their wild-type counterparts. For the first time, we show an opposing effect of the two TR isoforms, TRα1 and TRβ, in the regulation of state anxiety, with α1 knockout animals (α1KO) showing higher levels of anxiety and βKO males showing less anxiety compared to respective wild-type mice. At odds with the increased anxiety in non-social environments, α1KO males also show lower levels of responsiveness to acoustic and tactile startle stimuli. Consistent with the data that T4 is inhibitory to lordosis in female mice, we show subtly increased sex behavior in α1KO male mice. These behaviors support the idea that TRα1 could be inhibitory to ERα driven transcription that ultimately impacts ERα driven behaviors such as lordosis. The behavioral phenotypes point to novel roles for the TRs, particularly in non-social behaviors such as state anxiety and startle." @default.
- W2128003472 created "2016-06-24" @default.
- W2128003472 creator A5009561431 @default.
- W2128003472 creator A5018883620 @default.
- W2128003472 creator A5068564642 @default.
- W2128003472 creator A5086866710 @default.
- W2128003472 date "2013-05-01" @default.
- W2128003472 modified "2023-10-12" @default.
- W2128003472 title "Distinct behavioral phenotypes in male mice lacking the thyroid hormone receptor α1 or β isoforms" @default.
- W2128003472 cites W1504286609 @default.
- W2128003472 cites W1516263550 @default.
- W2128003472 cites W1587621508 @default.
- W2128003472 cites W1637259485 @default.
- W2128003472 cites W1781559158 @default.
- W2128003472 cites W1969420213 @default.
- W2128003472 cites W1971821112 @default.
- W2128003472 cites W1982410104 @default.
- W2128003472 cites W1982566905 @default.
- W2128003472 cites W1985010774 @default.
- W2128003472 cites W1985221328 @default.
- W2128003472 cites W1990555605 @default.
- W2128003472 cites W1990694352 @default.
- W2128003472 cites W1993602309 @default.
- W2128003472 cites W1994237441 @default.
- W2128003472 cites W1996271752 @default.
- W2128003472 cites W2004716057 @default.
- W2128003472 cites W2010662943 @default.
- W2128003472 cites W2013082402 @default.
- W2128003472 cites W2014086109 @default.
- W2128003472 cites W2014440955 @default.
- W2128003472 cites W2018750143 @default.
- W2128003472 cites W2021932599 @default.
- W2128003472 cites W2024292910 @default.
- W2128003472 cites W2027083548 @default.
- W2128003472 cites W2029157004 @default.
- W2128003472 cites W2029437124 @default.
- W2128003472 cites W2030392869 @default.
- W2128003472 cites W2030554335 @default.
- W2128003472 cites W2032837908 @default.
- W2128003472 cites W2034266830 @default.
- W2128003472 cites W2039938261 @default.
- W2128003472 cites W2047810860 @default.
- W2128003472 cites W2053252228 @default.
- W2128003472 cites W2053726639 @default.
- W2128003472 cites W2057682786 @default.
- W2128003472 cites W2057914362 @default.
- W2128003472 cites W2064278932 @default.
- W2128003472 cites W2066301097 @default.
- W2128003472 cites W2068616922 @default.
- W2128003472 cites W2070712357 @default.
- W2128003472 cites W2071666587 @default.
- W2128003472 cites W2072501211 @default.
- W2128003472 cites W2074132525 @default.
- W2128003472 cites W2074245141 @default.
- W2128003472 cites W2085222328 @default.
- W2128003472 cites W2087809665 @default.
- W2128003472 cites W2093727975 @default.
- W2128003472 cites W2096656736 @default.
- W2128003472 cites W2100301175 @default.
- W2128003472 cites W2101676483 @default.
- W2128003472 cites W2124328133 @default.
- W2128003472 cites W2125021723 @default.
- W2128003472 cites W2126038578 @default.
- W2128003472 cites W2128867321 @default.
- W2128003472 cites W2142640185 @default.
- W2128003472 cites W2156051638 @default.
- W2128003472 cites W2160166542 @default.
- W2128003472 cites W2162116401 @default.
- W2128003472 cites W2165022229 @default.
- W2128003472 cites W2167231164 @default.
- W2128003472 cites W266477159 @default.
- W2128003472 doi "https://doi.org/10.1016/j.yhbeh.2013.03.015" @default.
- W2128003472 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3726275" @default.
- W2128003472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23567476" @default.
- W2128003472 hasPublicationYear "2013" @default.
- W2128003472 type Work @default.
- W2128003472 sameAs 2128003472 @default.
- W2128003472 citedByCount "15" @default.
- W2128003472 countsByYear W21280034722014 @default.
- W2128003472 countsByYear W21280034722016 @default.
- W2128003472 countsByYear W21280034722017 @default.
- W2128003472 countsByYear W21280034722018 @default.
- W2128003472 countsByYear W21280034722019 @default.
- W2128003472 countsByYear W21280034722020 @default.
- W2128003472 countsByYear W21280034722021 @default.
- W2128003472 crossrefType "journal-article" @default.
- W2128003472 hasAuthorship W2128003472A5009561431 @default.
- W2128003472 hasAuthorship W2128003472A5018883620 @default.
- W2128003472 hasAuthorship W2128003472A5068564642 @default.
- W2128003472 hasAuthorship W2128003472A5086866710 @default.
- W2128003472 hasBestOaLocation W21280034722 @default.
- W2128003472 hasConcept C109115496 @default.
- W2128003472 hasConcept C118552586 @default.
- W2128003472 hasConcept C126322002 @default.
- W2128003472 hasConcept C134018914 @default.
- W2128003472 hasConcept C141421786 @default.
- W2128003472 hasConcept C15744967 @default.
- W2128003472 hasConcept C170493617 @default.