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• W2128018427 abstract "Compound rac-1 was identified by high throughput screening. Here we report SAR studies and MedChem optimization towards the highly potent dual orexin receptor antagonists (S)-2 and (S)-3. Furthermore, strategies to overcome the suboptimal physicochemical properties are highlighted and the pharmacokinetic profiles of representative compounds is presented." @default.
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• W2128018427 date "2015-12-01" @default.
• W2128018427 modified "2023-09-27" @default.
• W2128018427 title "Discovery of 1 H -pyrazolo[3,4- b ]pyridines as potent dual orexin receptor antagonists (DORAs)" @default.
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• W2128018427 doi "https://doi.org/10.1016/j.bmcl.2015.10.055" @default.
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