FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128021059> ?p ?o ?g. }

• W2128021059 endingPage "963" @default.
• W2128021059 startingPage "958" @default.
• W2128021059 abstract "Aprotinin has been associated with significant morbidity and mortality in adults, leading to its withdrawal from the market and clinical substitution with the lysine analogs, tranexamic acid and ε-aminocaproic acid. Neonates undergoing cardiopulmonary bypass are especially at risk for perioperative bleeding, yet little data exist comparing lysine analogs with aprotinin.Neonates undergoing cardiopulmonary bypass (January 2006 to December 2009) were included in this single-institution, retrospective cohort study. Preoperative, intraoperative, and postoperative data were analyzed. The relationship between demographic, surgical risk data, and outcomes were analyzed. Markers of effectiveness included transfusion requirement, duration of operation, duration of ventilation, and intensive care unit length of stay. Markers of safety included reexploration, renal dysfunction, neurologic complications, and death.Of 423 included neonates, 271 (64%) received aprotinin and 152 (36%) a lysine analog. Infants who received aprotinin had a higher baseline creatinine and lower weight and gestational age. The aprotinin group experienced shorter time to surgical closure, lower blood product use, and lower rates of reexploration and postoperative renal dysfunction compared with the lysine-analog group. There was no difference in duration of ventilation or intensive care unit stay, neurologic outcomes, or death.Neonates who received aprotinin had significantly lower intraoperative transfusion requirements and shorter surgical closure times. The aprotinin group was less likely to require surgical reexploration and had a lower rate of renal injury. These data illustrate the need for further research regarding safety and efficacy of aprotinin in a larger sample of children undergoing cardiac operations." @default.
• W2128021059 created "2016-06-24" @default.
• W2128021059 creator A5001739052 @default.
• W2128021059 creator A5004410700 @default.
• W2128021059 creator A5027720078 @default.
• W2128021059 creator A5053622406 @default.
• W2128021059 creator A5054287096 @default.
• W2128021059 creator A5086779033 @default.
• W2128021059 date "2011-09-01" @default.
• W2128021059 modified "2023-09-25" @default.
• W2128021059 title "Efficacy and Safety of Aprotinin in Neonatal Congenital Heart Operations" @default.
• W2128021059 cites W1920218088 @default.
• W2128021059 cites W1973914566 @default.
• W2128021059 cites W1978691495 @default.
• W2128021059 cites W1986299008 @default.
• W2128021059 cites W1987753624 @default.
• W2128021059 cites W1988081398 @default.
• W2128021059 cites W1995990736 @default.
• W2128021059 cites W1998076891 @default.
• W2128021059 cites W2003463282 @default.
• W2128021059 cites W2007679166 @default.
• W2128021059 cites W2011556467 @default.
• W2128021059 cites W2016328593 @default.
• W2128021059 cites W2016848644 @default.
• W2128021059 cites W2021449048 @default.
• W2128021059 cites W2026639883 @default.
• W2128021059 cites W2028424478 @default.
• W2128021059 cites W2043343988 @default.
• W2128021059 cites W2047881995 @default.
• W2128021059 cites W2050303747 @default.
• W2128021059 cites W2059629573 @default.
• W2128021059 cites W2062293192 @default.
• W2128021059 cites W2087572353 @default.
• W2128021059 cites W2089295053 @default.
• W2128021059 cites W2089662512 @default.
• W2128021059 cites W2092498025 @default.
• W2128021059 cites W2095173867 @default.
• W2128021059 cites W2096459479 @default.
• W2128021059 cites W2096967097 @default.
• W2128021059 cites W2100222319 @default.
• W2128021059 cites W2107522704 @default.
• W2128021059 cites W2117522468 @default.
• W2128021059 cites W2132035869 @default.
• W2128021059 cites W2143305384 @default.
• W2128021059 cites W2143505655 @default.
• W2128021059 cites W2156870897 @default.
• W2128021059 cites W2170024245 @default.
• W2128021059 cites W3021384959 @default.
• W2128021059 doi "https://doi.org/10.1016/j.athoracsur.2011.04.094" @default.
• W2128021059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21871283" @default.
• W2128021059 hasPublicationYear "2011" @default.
• W2128021059 type Work @default.
• W2128021059 sameAs 2128021059 @default.
• W2128021059 citedByCount "26" @default.
• W2128021059 countsByYear W21280210592012 @default.
• W2128021059 countsByYear W21280210592013 @default.
• W2128021059 countsByYear W21280210592014 @default.
• W2128021059 countsByYear W21280210592015 @default.
• W2128021059 countsByYear W21280210592016 @default.
• W2128021059 countsByYear W21280210592017 @default.
• W2128021059 countsByYear W21280210592019 @default.
• W2128021059 countsByYear W21280210592021 @default.
• W2128021059 countsByYear W21280210592022 @default.
• W2128021059 countsByYear W21280210592023 @default.
• W2128021059 crossrefType "journal-article" @default.
• W2128021059 hasAuthorship W2128021059A5001739052 @default.
• W2128021059 hasAuthorship W2128021059A5004410700 @default.
• W2128021059 hasAuthorship W2128021059A5027720078 @default.
• W2128021059 hasAuthorship W2128021059A5053622406 @default.
• W2128021059 hasAuthorship W2128021059A5054287096 @default.
• W2128021059 hasAuthorship W2128021059A5086779033 @default.
• W2128021059 hasConcept C126322002 @default.
• W2128021059 hasConcept C141071460 @default.
• W2128021059 hasConcept C167135981 @default.
• W2128021059 hasConcept C187212893 @default.
• W2128021059 hasConcept C2776376669 @default.
• W2128021059 hasConcept C2777080012 @default.
• W2128021059 hasConcept C2777091541 @default.
• W2128021059 hasConcept C2777396833 @default.
• W2128021059 hasConcept C2778376644 @default.
• W2128021059 hasConcept C2778881276 @default.
• W2128021059 hasConcept C2779234561 @default.
• W2128021059 hasConcept C2779637338 @default.
• W2128021059 hasConcept C2780799893 @default.
• W2128021059 hasConcept C2781436528 @default.
• W2128021059 hasConcept C2991743468 @default.
• W2128021059 hasConcept C31174226 @default.
• W2128021059 hasConcept C42219234 @default.
• W2128021059 hasConcept C54355233 @default.
• W2128021059 hasConcept C71924100 @default.
• W2128021059 hasConcept C86803240 @default.
• W2128021059 hasConceptScore W2128021059C126322002 @default.
• W2128021059 hasConceptScore W2128021059C141071460 @default.
• W2128021059 hasConceptScore W2128021059C167135981 @default.
• W2128021059 hasConceptScore W2128021059C187212893 @default.
• W2128021059 hasConceptScore W2128021059C2776376669 @default.
• W2128021059 hasConceptScore W2128021059C2777080012 @default.
• W2128021059 hasConceptScore W2128021059C2777091541 @default.

• next