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• W2128022499 abstract "Objective To study age-related metabolic changes in N-acetylaspartate (NAA), total creatine (tCr), choline (Cho) and myo-inositol (Ins). Materials and methods Proton magnetic resonance spectroscopy (1H-MRS) was performed in the posterior cingulate cortex (PCC) and the left hippocampus (HC) of 90 healthy subjects (42 women and 48 men aged 18–76 years, mean ± SD, 48.4 ± 16.8 years). Both metabolite ratios and absolute metabolite concentrations were evaluated. Analysis of covariance (ANCOVA) and linear regression were used for statistical analysis. Results Metabolite ratios Ins/tCr and Ins/H2O were found significantly increased with age in the PCC (P < 0.05 and P ≤ 0.001, respectively), and in the HC (P < 0.01 for both). An increased tCr/H2O was only observed in the PCC (P < 0.01). Following absolute quantification based on the internal water signal, significantly increased concentrations of Ins and tCr in the PCC confirmed the relative findings (P < 0.01 for both). Conclusion Age-related increases of tCr and Ins are found in the PCC, whereas this holds only true for Ins in the HC, indicating possible gliosis in the ageing brain. No age-dependent NAA decreases were observed in the PCC nor the HC. The 1H-MRS results in these specific brain regions can be important to differentiate normal ageing from age-related pathologies such as mild cognitive impairment (MCI) and Alzheimer's disease." @default.
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• W2128022499 date "2012-03-01" @default.
• W2128022499 modified "2023-10-14" @default.
• W2128022499 title "Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: A 1H-MRS study" @default.
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• W2128022499 doi "https://doi.org/10.1016/j.ejrad.2011.01.106" @default.
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