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• W2128032939 abstract "Using streptozotocin-induced diabetic Wistar rats, studies were carried out to examine the metabolic availability of vitamin A in the plasma, liver and the retina of the eye. Control and diabetic rats were fed ad lib . on a semi-purified diet either with or without (basal) vitamin A supplementation, or pair-fed on the basal diet for 4 weeks. Despite the fact that diabeticrats consumed 48% more feed, they had lower plasma concentrations of retinol ( P <0·003). The decrease in plasma retinol concentration was a response to diabetes (or diabetes-induced trauma), since neither pair-feeding ( P <0·01) nor vitamin A supplementation altered this effect ( P <0·05). Furthermore, the hepatic concentrations of the vitamin in these animals remained elevated and this increase was greater in the supplemented diabetic group ( P <0·001). Decreases in 11-cis retinal (a component of rhodopsin) concentrations in the retina were also observed in diabetic animals. The increased hepatic and the decreased plasma and retina vitamin Alevels suggest a defect in the transport of the vitamin from the liver." @default.
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• W2128032939 date "1996-04-01" @default.
• W2128032939 modified "2023-09-26" @default.
• W2128032939 title "Streptozotocin-induced diabetes in rats is associated with impaired metabolic availability of vitamin A (retinol)" @default.
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• W2128032939 doi "https://doi.org/10.1079/bjn19960164" @default.
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