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- W2128040354 abstract "Indolemine 2, 3-dioxygenase (IDO) is a cytosolic monomeric hemoprotein enzyme that catalyses tryptophan, the least available essential amino acid in the human body, to N-formylkynurenine, which in turn rapidly degrades to give kynurenine. IDO is expressed in different tissues, especially and prominently in some subsets of antigen presenting cells (APCs) of lymphoid organs and also in the placenta of human and other mammals. Expression of IDO by certain dendritic cells, monocytes and macrophages has a regulatory effect on T cells probably by providing a tryptophan-deficient microenvironment and/or accumulation of toxic metabolites of tryptophan. This immunomodulatory function of IDO plays an essential role in different physiological and pathological states. IDO was shown to prevent rejection of the fetus during pregnancy, possibly by inhibiting alloreactive T cells. Moreover, IDO expression in APCs was suggested to control autoreactive immune responses. In this review we discuss the molecular and biological characteristics of IDO and its function in immune system as well as the potential application of this enzyme in improving the outcome of allogeneic transplantation as a local immunosuppressive factor." @default.
- W2128040354 created "2016-06-24" @default.
- W2128040354 creator A5011013562 @default.
- W2128040354 creator A5031318835 @default.
- W2128040354 creator A5063403933 @default.
- W2128040354 creator A5070746513 @default.
- W2128040354 date "2007-12-01" @default.
- W2128040354 modified "2023-09-26" @default.
- W2128040354 title "The Immunoregulatory Function of Indoleamine 2, 3 Dioxygenase and Its Application in Allotransplantation" @default.
- W2128040354 cites W1512372665 @default.
- W2128040354 cites W158023586 @default.
- W2128040354 cites W1593588462 @default.
- W2128040354 cites W1598309391 @default.
- W2128040354 cites W1632787824 @default.
- W2128040354 cites W1677467555 @default.
- W2128040354 cites W1834981029 @default.
- W2128040354 cites W1857082171 @default.
- W2128040354 cites W1936852270 @default.
- W2128040354 cites W1947375451 @default.
- W2128040354 cites W1963793094 @default.
- W2128040354 cites W1971486945 @default.
- W2128040354 cites W1971884703 @default.
- W2128040354 cites W1974401900 @default.
- W2128040354 cites W1975336695 @default.
- W2128040354 cites W1975929837 @default.
- W2128040354 cites W1976641851 @default.
- W2128040354 cites W1977380476 @default.
- W2128040354 cites W1977759111 @default.
- W2128040354 cites W1977831876 @default.
- W2128040354 cites W1978741561 @default.
- W2128040354 cites W1982809278 @default.
- W2128040354 cites W1984584304 @default.
- W2128040354 cites W1984736455 @default.
- W2128040354 cites W1991999080 @default.
- W2128040354 cites W1999601075 @default.
- W2128040354 cites W2002301175 @default.
- W2128040354 cites W2004806121 @default.
- W2128040354 cites W2006770834 @default.
- W2128040354 cites W2010378562 @default.
- W2128040354 cites W2014423141 @default.
- W2128040354 cites W2015260577 @default.
- W2128040354 cites W2016242021 @default.
- W2128040354 cites W2020818730 @default.
- W2128040354 cites W2026332699 @default.
- W2128040354 cites W2027821655 @default.
- W2128040354 cites W2029060578 @default.
- W2128040354 cites W2037671952 @default.
- W2128040354 cites W2037920661 @default.
- W2128040354 cites W2043971574 @default.
- W2128040354 cites W2044068299 @default.
- W2128040354 cites W2047135493 @default.
- W2128040354 cites W205568925 @default.
- W2128040354 cites W2057001364 @default.
- W2128040354 cites W2057709162 @default.
- W2128040354 cites W2060331962 @default.
- W2128040354 cites W2063144795 @default.
- W2128040354 cites W2065151741 @default.
- W2128040354 cites W2068275862 @default.
- W2128040354 cites W2070311659 @default.
- W2128040354 cites W2072078248 @default.
- W2128040354 cites W2073144071 @default.
- W2128040354 cites W2075224966 @default.
- W2128040354 cites W2080187002 @default.
- W2128040354 cites W2081369594 @default.
- W2128040354 cites W2085802461 @default.
- W2128040354 cites W2086002861 @default.
- W2128040354 cites W2088828149 @default.
- W2128040354 cites W2090410108 @default.
- W2128040354 cites W2105117087 @default.
- W2128040354 cites W2105567566 @default.
- W2128040354 cites W2110651507 @default.
- W2128040354 cites W2114079476 @default.
- W2128040354 cites W2117446006 @default.
- W2128040354 cites W2119939110 @default.
- W2128040354 cites W2120343652 @default.
- W2128040354 cites W2122285073 @default.
- W2128040354 cites W2123735453 @default.
- W2128040354 cites W2123812720 @default.
- W2128040354 cites W2127848114 @default.
- W2128040354 cites W2128867995 @default.
- W2128040354 cites W2131999220 @default.
- W2128040354 cites W2138558289 @default.
- W2128040354 cites W2143565660 @default.
- W2128040354 cites W2146914242 @default.
- W2128040354 cites W2146934919 @default.
- W2128040354 cites W2152524078 @default.
- W2128040354 cites W2152857351 @default.
- W2128040354 cites W2157249839 @default.
- W2128040354 cites W2157445809 @default.
- W2128040354 cites W2160827995 @default.
- W2128040354 cites W2163828684 @default.
- W2128040354 cites W2164713036 @default.
- W2128040354 cites W2166318113 @default.
- W2128040354 cites W2167897482 @default.
- W2128040354 cites W2354928181 @default.
- W2128040354 cites W2397320519 @default.
- W2128040354 cites W247737228 @default.
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