FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128043787> ?p ?o ?g. }

• W2128043787 abstract "TP53 is a central hub integrating stress signals from oncogenic genetic lesions and cytotoxic anti-cancer agents. The function of p53 as a regulator of transcription is well documented. More recently it was shown to directly interact with BCL2 family members and induce mitochondrial cell death. Stress-induced activation of p53 leads to cell cycle arrest that allows metabolic adjustments and repair mechanisms to take place prior to the next cycle; p53 may also induce senescence or apoptosis depending on the strength and nature of stress stimuli and/or cell type. In 50% of human cancers, the TP53 gene is deleted or mutated with a high proportion of gain of oncogenic function mutations. It is noteworthy therefore that TP53 is rarely mutated in T-ALL. However, its tumor suppressor activity is circumvented by genetic lesions. We will discuss here the most frequent T-ALL genetic abnormalities of INK4A/ARF, NOTCH1 and PTEN genes and how they affect TP53 expression and function. Current understanding of the signaling pathways governed by these oncogenes is advanced enough to find points of intersection with p53 downstream targets and attempt to translate the accumulated knowledge to the clinic. In addition, we will discuss the results of our analysis of publicly available expression profiling data indicating the existence of a TP53-anchored transcriptional program targeted by T-ALL oncogenes such as NOTCH, MYC and TLX1 in primary leukemic cells and how it can be exploited for cancer intervention. Overall, the goal of this chapter is to describe how T-ALL pathobiology affects the p53interacting network, highlighting some new potential therapeutic targets as well as some still unresolved questions." @default.
• W2128043787 created "2016-06-24" @default.
• W2128043787 creator A5031658033 @default.
• W2128043787 creator A5061119042 @default.
• W2128043787 creator A5073126483 @default.
• W2128043787 creator A5089781170 @default.
• W2128043787 date "2011-11-16" @default.
• W2128043787 modified "2023-09-25" @default.
• W2128043787 title "p53 as a Therapeutic Target in T-ALL" @default.
• W2128043787 cites W1481473039 @default.
• W2128043787 cites W1485459479 @default.
• W2128043787 cites W1526564054 @default.
• W2128043787 cites W1526999767 @default.
• W2128043787 cites W1549261396 @default.
• W2128043787 cites W1560780012 @default.
• W2128043787 cites W1750359001 @default.
• W2128043787 cites W1936655991 @default.
• W2128043787 cites W1951801079 @default.
• W2128043787 cites W1965912619 @default.
• W2128043787 cites W1966805549 @default.
• W2128043787 cites W1968515645 @default.
• W2128043787 cites W1968710367 @default.
• W2128043787 cites W1969204301 @default.
• W2128043787 cites W1971368930 @default.
• W2128043787 cites W1972780353 @default.
• W2128043787 cites W1973850616 @default.
• W2128043787 cites W1980083899 @default.
• W2128043787 cites W1981156814 @default.
• W2128043787 cites W1981915151 @default.
• W2128043787 cites W1982023788 @default.
• W2128043787 cites W1982395176 @default.
• W2128043787 cites W1989168159 @default.
• W2128043787 cites W1993240075 @default.
• W2128043787 cites W1993246806 @default.
• W2128043787 cites W1994045067 @default.
• W2128043787 cites W1994791278 @default.
• W2128043787 cites W1995421851 @default.
• W2128043787 cites W1997801717 @default.
• W2128043787 cites W2000589976 @default.
• W2128043787 cites W2000617957 @default.
• W2128043787 cites W2003307365 @default.
• W2128043787 cites W2003750107 @default.
• W2128043787 cites W200461798 @default.
• W2128043787 cites W2005056727 @default.
• W2128043787 cites W2006613419 @default.
• W2128043787 cites W2007249806 @default.
• W2128043787 cites W2007674386 @default.
• W2128043787 cites W2007710816 @default.
• W2128043787 cites W2009351714 @default.
• W2128043787 cites W2009700765 @default.
• W2128043787 cites W2009880140 @default.
• W2128043787 cites W2010204335 @default.
• W2128043787 cites W2010468747 @default.
• W2128043787 cites W2012538791 @default.
• W2128043787 cites W2014096417 @default.
• W2128043787 cites W2018527149 @default.
• W2128043787 cites W2018769121 @default.
• W2128043787 cites W2019361551 @default.
• W2128043787 cites W2020084014 @default.
• W2128043787 cites W2023550246 @default.
• W2128043787 cites W2024945535 @default.
• W2128043787 cites W2025388074 @default.
• W2128043787 cites W2025722611 @default.
• W2128043787 cites W2025998282 @default.
• W2128043787 cites W2028210102 @default.
• W2128043787 cites W2028592091 @default.
• W2128043787 cites W2028885330 @default.
• W2128043787 cites W2033537445 @default.
• W2128043787 cites W2034042949 @default.
• W2128043787 cites W2038444562 @default.
• W2128043787 cites W2039171339 @default.
• W2128043787 cites W2039433529 @default.
• W2128043787 cites W2041143043 @default.
• W2128043787 cites W2041175983 @default.
• W2128043787 cites W2042461504 @default.
• W2128043787 cites W2044826816 @default.
• W2128043787 cites W2046267268 @default.
• W2128043787 cites W2049184223 @default.
• W2128043787 cites W2049396238 @default.
• W2128043787 cites W2051821952 @default.
• W2128043787 cites W2052609775 @default.
• W2128043787 cites W2053820532 @default.
• W2128043787 cites W2056171399 @default.
• W2128043787 cites W2056495027 @default.
• W2128043787 cites W2057403210 @default.
• W2128043787 cites W2058106363 @default.
• W2128043787 cites W2058576055 @default.
• W2128043787 cites W2058631780 @default.
• W2128043787 cites W2064589139 @default.
• W2128043787 cites W2066848701 @default.
• W2128043787 cites W2066899457 @default.
• W2128043787 cites W2067734857 @default.
• W2128043787 cites W2067751798 @default.
• W2128043787 cites W2068912983 @default.
• W2128043787 cites W2069408483 @default.
• W2128043787 cites W2070422421 @default.
• W2128043787 cites W2075291089 @default.
• W2128043787 cites W2076411120 @default.
• W2128043787 cites W2077262087 @default.
• W2128043787 cites W2077582389 @default.

• next