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- W2128045402 abstract "β-catenin is an intracellular signaling molecule that has been shown to be important in activity-dependent dendritic morphogenesis. Here, we investigate the detailed morphological changes elicited in dendritic arbors of cultured hippocampal neurons by overexpression of β-catenin, and we simulate the electrophysiological consequences of these changes. Compared to control neurons, cells overexpressing β-catenin have dendritic arbors with significantly greater surface area and more branches, as well as different topological characteristics. To investigate possible effects of β-catenin expression on the electrophysiological properties of neurons, we converted confocal images of neurons expressing β-catenin into computational simulator formats using parameters that evenly distributed voltage-dependent channels across the cells’ membranes. In simulated current clamp experiments, somata were injected with a normalized current such that the observed electrophysiological differences in the neurons would be due only to morphological differences. We found that the morphology of β-catenin-expressing neurons contributes to significantly smaller action potential amplitude and greater sensitivity than seen in control neurons. As a consequence, β-catenin-expressing neurons tended to exhibit higher spike rates and needed less excitation to induce firing. These findings show that β-catenin, by modifying dendritic arborization, could have profound influences on the electrophysiological behavior of neurons." @default.
- W2128045402 created "2016-06-24" @default.
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- W2128045402 date "2006-08-01" @default.
- W2128045402 modified "2023-10-16" @default.
- W2128045402 title "Effects of β-Catenin on Dendritic Morphology and Simulated Firing Patterns in Cultured Hippocampal Neurons" @default.
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- W2128045402 doi "https://doi.org/10.2307/4134575" @default.
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