FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128082005> ?p ?o ?g. }

• W2128082005 endingPage "3247" @default.
• W2128082005 startingPage "3237" @default.
• W2128082005 abstract "The metabolism of arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) is thought to be mediated primarily by the cytochromes P450 (P450s) from the 2 family (2C9, 2C19, 2D6, and 2J2). In contrast, P450s of the 4 family are primarily involved in omega oxidation of AA (4A11 and 4A22). The ability to determine enantioselective formation of the regioisomeric EETs is important in order to establish their potential biological activities and to asses which P450 isoforms are involved in their formation. It has been extremely difficult to analyze individual EET enantiomers in biological fluids because they are present in only trace amounts and they are extremely difficult to separate from each other. In addition, the deuterium-labeled internal standards that are commonly used for stable isotope dilution liquid chromatography/mass spectrometry (LC/MS) analyses have different LC retention times when compared with the corresponding protium forms. Therefore, quantification by LC/MS-based methodology can be compromised by differential suppression of ionization of the closely eluting isomers. We report the preparation of [(13)C(20)]-EET analog internal standards and the use of a validated high-sensitivity chiral LC/electron capture atmospheric pressure chemical ionization (ECAPCI)-MS method for the trace analysis of endogenous EETs as their pentafluorobenzyl (PFB) ester derivatives. The assay was then used to show the exquisite enantioselectivity of P4502C19-, P4502D6-, P4501A1-, and P4501B1-mediated conversion of AA into EETs and to quantify the enantioselective formation of EETs produced by AA metabolism in a mouse epithelial hepatoma (Hepa) cell line." @default.
• W2128082005 created "2016-06-24" @default.
• W2128082005 creator A5003571844 @default.
• W2128082005 creator A5007007052 @default.
• W2128082005 creator A5079384190 @default.
• W2128082005 date "2010-10-15" @default.
• W2128082005 modified "2023-10-17" @default.
• W2128082005 title "Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [¹³C]-analog internal standards" @default.
• W2128082005 cites W1483553420 @default.
• W2128082005 cites W1489520434 @default.
• W2128082005 cites W1529262696 @default.
• W2128082005 cites W1578135150 @default.
• W2128082005 cites W1681118386 @default.
• W2128082005 cites W1908520885 @default.
• W2128082005 cites W1913730804 @default.
• W2128082005 cites W1968011115 @default.
• W2128082005 cites W1974556160 @default.
• W2128082005 cites W1992303064 @default.
• W2128082005 cites W1993404169 @default.
• W2128082005 cites W1994554038 @default.
• W2128082005 cites W1996954653 @default.
• W2128082005 cites W1997036567 @default.
• W2128082005 cites W2000589939 @default.
• W2128082005 cites W2017605264 @default.
• W2128082005 cites W2019303947 @default.
• W2128082005 cites W2020712150 @default.
• W2128082005 cites W2022637465 @default.
• W2128082005 cites W2023362496 @default.
• W2128082005 cites W2027612574 @default.
• W2128082005 cites W2031151357 @default.
• W2128082005 cites W2033271350 @default.
• W2128082005 cites W2036840895 @default.
• W2128082005 cites W2037113953 @default.
• W2128082005 cites W2039628688 @default.
• W2128082005 cites W2050090021 @default.
• W2128082005 cites W2050615800 @default.
• W2128082005 cites W2054780459 @default.
• W2128082005 cites W2061608251 @default.
• W2128082005 cites W2062628482 @default.
• W2128082005 cites W2063486154 @default.
• W2128082005 cites W2068048960 @default.
• W2128082005 cites W2072567200 @default.
• W2128082005 cites W2077945512 @default.
• W2128082005 cites W2082154986 @default.
• W2128082005 cites W2084655984 @default.
• W2128082005 cites W2094826866 @default.
• W2128082005 cites W2095517739 @default.
• W2128082005 cites W2113524447 @default.
• W2128082005 cites W2125549965 @default.
• W2128082005 cites W2135910732 @default.
• W2128082005 cites W2144220511 @default.
• W2128082005 cites W2151263304 @default.
• W2128082005 cites W2155529149 @default.
• W2128082005 cites W2159079439 @default.
• W2128082005 cites W2163987489 @default.
• W2128082005 cites W2168526937 @default.
• W2128082005 cites W2171907478 @default.
• W2128082005 cites W298015312 @default.
• W2128082005 cites W944320809 @default.
• W2128082005 doi "https://doi.org/10.1002/rcm.4760" @default.
• W2128082005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3348553" @default.
• W2128082005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20972997" @default.
• W2128082005 hasPublicationYear "2010" @default.
• W2128082005 type Work @default.
• W2128082005 sameAs 2128082005 @default.
• W2128082005 citedByCount "27" @default.
• W2128082005 countsByYear W21280820052012 @default.
• W2128082005 countsByYear W21280820052013 @default.
• W2128082005 countsByYear W21280820052014 @default.
• W2128082005 countsByYear W21280820052016 @default.
• W2128082005 countsByYear W21280820052017 @default.
• W2128082005 countsByYear W21280820052018 @default.
• W2128082005 countsByYear W21280820052019 @default.
• W2128082005 countsByYear W21280820052020 @default.
• W2128082005 countsByYear W21280820052021 @default.
• W2128082005 countsByYear W21280820052022 @default.
• W2128082005 countsByYear W21280820052023 @default.
• W2128082005 crossrefType "journal-article" @default.
• W2128082005 hasAuthorship W2128082005A5003571844 @default.
• W2128082005 hasAuthorship W2128082005A5007007052 @default.
• W2128082005 hasAuthorship W2128082005A5079384190 @default.
• W2128082005 hasBestOaLocation W21280820052 @default.
• W2128082005 hasConcept C145148216 @default.
• W2128082005 hasConcept C148065180 @default.
• W2128082005 hasConcept C162356407 @default.
• W2128082005 hasConcept C178790620 @default.
• W2128082005 hasConcept C185592680 @default.
• W2128082005 hasConcept C198291218 @default.
• W2128082005 hasConcept C43617362 @default.
• W2128082005 hasConcept C486523 @default.
• W2128082005 hasConcept C51884965 @default.
• W2128082005 hasConcept C64489805 @default.
• W2128082005 hasConcept C71240020 @default.
• W2128082005 hasConceptScore W2128082005C145148216 @default.
• W2128082005 hasConceptScore W2128082005C148065180 @default.
• W2128082005 hasConceptScore W2128082005C162356407 @default.
• W2128082005 hasConceptScore W2128082005C178790620 @default.
• W2128082005 hasConceptScore W2128082005C185592680 @default.

• next