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- W2128131410 abstract "There is lack of data with regard to FLT3 expression in FLT3-ITD positive pediatric AML patients. Further, FLT3-ITD has not been systematically analyzed for outcome from Indian subcontinent. Amongst 64 consecutive pediatric AML patients, FLT3-ITD was present in 12 (19%) patients. All patients with FLT3-ITD achieved CR; those with FLT3-ITD mutation had inferior DFS (P = .029). FLT3 expression by flow-cytometry was observed in all FLT3-ITD positive patients, whereas 40/52 (77%) FLT3-ITD negative patients expressed FLT3 (P = .06). FLT3 expression in 12 FLT3-ITD positive patients was unable to show an association between FLT3 expression and outcome. In FLT3-ITD negative patients, higher surface expression of FLT3 significantly predicted poor EFS (P = .001) and OS (P = .007)." @default.
- W2128131410 created "2016-06-24" @default.
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- W2128131410 date "2014-02-05" @default.
- W2128131410 modified "2023-10-16" @default.
- W2128131410 title "FLT3-ITD Mutation in Relation to FLT3 Expression in Pediatric AML: A Prospective Study from India" @default.
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- W2128131410 doi "https://doi.org/10.3109/08880018.2013.870624" @default.
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