FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128186768> ?p ?o ?g. }

• W2128186768 endingPage "471" @default.
• W2128186768 startingPage "464" @default.
• W2128186768 abstract "Abstract The detection of changes in glucose level constitutes the first step of the control of glucose homeostasis. Glucose sensors are therefore expected to be present in different parts of the body and particularly in the central nervous system. Some studies have already attempted to determine glucose‐sensitive cerebral structures either after a glucoprivic stimulus or after prolonged hyperglycaemia. By analogy to beta cells, it was postulated that the glucose sensors in the brain could involve GLUT2, glucokinase and/or ATP‐sensitive K + channels. Surprisingly, GLUT2 was mainly found in astrocytes. Thus, the aims of the present investigation were to determine, in awake rats: (i) the hypothalamic areas that respond to acute hyperglycaemic condition induced by an intracarotid injection of glucose and (ii) the involvement of astrocytes in glucose‐sensing by the use of a glial drug, methionine sulfoximine. Rats were given intracarotid injections of glucose solution to trigger a transient insulin secretion without change in peripheral glycaemia, thus involving only central nervous regulation. Hypothalamic activation was determined by immunodetection of the immediate early gene c‐ fos protein. Acute glucose injection induces significant activation of arcuate and paraventricular nuclei. This stimulation mainly affects neurones in both nuclei, but also astrocytes in the former as illustrated by double immunohistochemistry (Fos and neuronal nuclei or glial fibrillary acidic protein). After specific impairment of astrocyte metabolism by methionine sulfoximine, cerebral activation disappears in the arcuate nucleus, correlated with the lack of cerebral glucose‐induced insulin secretion. Therefore, arcuate and paraventricular hypothalamic nuclei are able to detect acute cerebral hyperglycaemia, leading to a peripheral stimulation of insulin secretion. Arcuate nucleus and more especially astrocytes in this nucleus play a pivotal role in glucose‐sensing." @default.
• W2128186768 created "2016-06-24" @default.
• W2128186768 creator A5014708404 @default.
• W2128186768 creator A5053617026 @default.
• W2128186768 creator A5070213006 @default.
• W2128186768 creator A5090670823 @default.
• W2128186768 date "2004-04-29" @default.
• W2128186768 modified "2023-10-16" @default.
• W2128186768 title "Acute Intracarotid Glucose Injection Towards the Brain Induces Specific c-fos Activation in Hypothalamic Nuclei: Involvement of Astrocytes in Cerebral Glucose-Sensing in Rats" @default.
• W2128186768 cites W1487837909 @default.
• W2128186768 cites W1523394366 @default.
• W2128186768 cites W1561443084 @default.
• W2128186768 cites W1968750290 @default.
• W2128186768 cites W1978303221 @default.
• W2128186768 cites W1979132749 @default.
• W2128186768 cites W1979995256 @default.
• W2128186768 cites W1980021607 @default.
• W2128186768 cites W1983515350 @default.
• W2128186768 cites W1987390815 @default.
• W2128186768 cites W1999565511 @default.
• W2128186768 cites W2010464096 @default.
• W2128186768 cites W2016772458 @default.
• W2128186768 cites W2039518420 @default.
• W2128186768 cites W2039598915 @default.
• W2128186768 cites W2040186554 @default.
• W2128186768 cites W2045343277 @default.
• W2128186768 cites W2058363104 @default.
• W2128186768 cites W2061116118 @default.
• W2128186768 cites W2069501703 @default.
• W2128186768 cites W2072573580 @default.
• W2128186768 cites W2073694854 @default.
• W2128186768 cites W2075437215 @default.
• W2128186768 cites W2083132249 @default.
• W2128186768 cites W2092236026 @default.
• W2128186768 cites W2094163014 @default.
• W2128186768 cites W2099781923 @default.
• W2128186768 cites W2101907423 @default.
• W2128186768 cites W2115810166 @default.
• W2128186768 cites W2120625653 @default.
• W2128186768 cites W2122229485 @default.
• W2128186768 cites W2139155172 @default.
• W2128186768 cites W2141655027 @default.
• W2128186768 cites W2154628078 @default.
• W2128186768 cites W2158496649 @default.
• W2128186768 cites W2166911878 @default.
• W2128186768 cites W2170772645 @default.
• W2128186768 cites W2178963972 @default.
• W2128186768 cites W2188000153 @default.
• W2128186768 cites W2198406525 @default.
• W2128186768 cites W2276011769 @default.
• W2128186768 cites W2337494436 @default.
• W2128186768 cites W39967800 @default.
• W2128186768 doi "https://doi.org/10.1111/j.1365-2826.2004.01185.x" @default.
• W2128186768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15117340" @default.
• W2128186768 hasPublicationYear "2004" @default.
• W2128186768 type Work @default.
• W2128186768 sameAs 2128186768 @default.
• W2128186768 citedByCount "75" @default.
• W2128186768 countsByYear W21281867682012 @default.
• W2128186768 countsByYear W21281867682013 @default.
• W2128186768 countsByYear W21281867682014 @default.
• W2128186768 countsByYear W21281867682015 @default.
• W2128186768 countsByYear W21281867682016 @default.
• W2128186768 countsByYear W21281867682017 @default.
• W2128186768 countsByYear W21281867682018 @default.
• W2128186768 countsByYear W21281867682019 @default.
• W2128186768 countsByYear W21281867682020 @default.
• W2128186768 countsByYear W21281867682021 @default.
• W2128186768 countsByYear W21281867682022 @default.
• W2128186768 countsByYear W21281867682023 @default.
• W2128186768 crossrefType "journal-article" @default.
• W2128186768 hasAuthorship W2128186768A5014708404 @default.
• W2128186768 hasAuthorship W2128186768A5053617026 @default.
• W2128186768 hasAuthorship W2128186768A5070213006 @default.
• W2128186768 hasAuthorship W2128186768A5090670823 @default.
• W2128186768 hasConcept C126322002 @default.
• W2128186768 hasConcept C134018914 @default.
• W2128186768 hasConcept C161573976 @default.
• W2128186768 hasConcept C17093226 @default.
• W2128186768 hasConcept C185592680 @default.
• W2128186768 hasConcept C2777003273 @default.
• W2128186768 hasConcept C2777542381 @default.
• W2128186768 hasConcept C2777866211 @default.
• W2128186768 hasConcept C2777901630 @default.
• W2128186768 hasConcept C2778458369 @default.
• W2128186768 hasConcept C2779306644 @default.
• W2128186768 hasConcept C529278444 @default.
• W2128186768 hasConcept C71924100 @default.
• W2128186768 hasConcept C86803240 @default.
• W2128186768 hasConceptScore W2128186768C126322002 @default.
• W2128186768 hasConceptScore W2128186768C134018914 @default.
• W2128186768 hasConceptScore W2128186768C161573976 @default.
• W2128186768 hasConceptScore W2128186768C17093226 @default.
• W2128186768 hasConceptScore W2128186768C185592680 @default.
• W2128186768 hasConceptScore W2128186768C2777003273 @default.
• W2128186768 hasConceptScore W2128186768C2777542381 @default.
• W2128186768 hasConceptScore W2128186768C2777866211 @default.
• W2128186768 hasConceptScore W2128186768C2777901630 @default.

• next