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- W2128201302 abstract "Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semi-quantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generates a composite assessment of ‘strong’, ‘moderate’ or ‘weak’ epidemiological credibility. In addition, we discuss how additional input and guidance can be derived from biological data. Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors." @default.
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- W2128201302 date "2007-09-26" @default.
- W2128201302 modified "2023-10-11" @default.
- W2128201302 title "Assessment of cumulative evidence on genetic associations: interim guidelines" @default.
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- W2128201302 doi "https://doi.org/10.1093/ije/dym159" @default.
- W2128201302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17898028" @default.
- W2128201302 hasPublicationYear "2007" @default.