FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128220530> ?p ?o ?g. }

• W2128220530 endingPage "1294" @default.
• W2128220530 startingPage "1288" @default.
• W2128220530 abstract "Pancreastatin (PST), a chromogranin A-derived peptide, has counterregulatory effects on insulin in the hepatocyte and the adipocyte, suggesting a possible role in insulin resistance. The mechanism of PST action on glucose and lipid metabolism is typical of a calcium-mobilizing hormone and involves a receptor Gq/11 protein-phospholipase C (PLC)-beta pathway. In the rat adipocyte, PST inhibits insulin-mediated glucose transport, glucose utilization, and lipid synthesis, and it has a lipolytic effect but stimulates basal and insulin-stimulated protein synthesis. We have also recently studied the PST receptor-effector system in adipocyte membranes. To further investigate the mechanisms of PST effect on insulin action, we studied the cross-talk of PST with insulin signaling in the rat adipocyte. We found that PST inhibits insulin-stimulated GLUT4 translocation to the membrane, which may explain the reported inhibition of glucose transport. Tyrosine phosphorylation of the activated insulin receptor, insulin receptor substrate (IRS)-1, and p60-70 was also blunted, preventing their association with p85 phosphatidylinositol 3-kinase (PI3K) and their activity. The mechanism of this inhibition involves the activation of the classical protein kinase C isoforms and the serine phosphorylation of insulin receptor and IRS-1. On the other hand, PST activates the mitogen-activated protein kinase (MAPK) signaling module and enhances the effect of insulin. This pathway may account for the described effect of PST on protein synthesis. In conclusion, PST seems to inhibit the insulin-stimulated PI3K pathway in the adipocyte, whereas it activates the MAPK pathway. These data provide some clues to the PST cross-talk with insulin signaling that may explain the PST effects on glucose metabolism and protein synthesis." @default.
• W2128220530 created "2016-06-24" @default.
• W2128220530 creator A5038461805 @default.
• W2128220530 creator A5040844908 @default.
• W2128220530 date "2000-08-01" @default.
• W2128220530 modified "2023-10-18" @default.
• W2128220530 title "Pancreastatin modulates insulin signaling in rat adipocytes: mechanisms of cross-talk." @default.
• W2128220530 cites W1479869774 @default.
• W2128220530 cites W1529636865 @default.
• W2128220530 cites W1531982572 @default.
• W2128220530 cites W1548475368 @default.
• W2128220530 cites W1554187190 @default.
• W2128220530 cites W1570629413 @default.
• W2128220530 cites W1572009433 @default.
• W2128220530 cites W1577661614 @default.
• W2128220530 cites W1602599763 @default.
• W2128220530 cites W1822231162 @default.
• W2128220530 cites W1947575656 @default.
• W2128220530 cites W1955990902 @default.
• W2128220530 cites W1965172707 @default.
• W2128220530 cites W1970203013 @default.
• W2128220530 cites W1972513995 @default.
• W2128220530 cites W1980393471 @default.
• W2128220530 cites W1981549168 @default.
• W2128220530 cites W1986232570 @default.
• W2128220530 cites W1986718205 @default.
• W2128220530 cites W1992899194 @default.
• W2128220530 cites W1995527862 @default.
• W2128220530 cites W1995890584 @default.
• W2128220530 cites W2002250942 @default.
• W2128220530 cites W2003659422 @default.
• W2128220530 cites W2012005883 @default.
• W2128220530 cites W2016563891 @default.
• W2128220530 cites W2025549832 @default.
• W2128220530 cites W2030338284 @default.
• W2128220530 cites W2030581242 @default.
• W2128220530 cites W2042914459 @default.
• W2128220530 cites W2044581908 @default.
• W2128220530 cites W2045976404 @default.
• W2128220530 cites W2047170656 @default.
• W2128220530 cites W2047614532 @default.
• W2128220530 cites W2048440906 @default.
• W2128220530 cites W2051521016 @default.
• W2128220530 cites W2052540197 @default.
• W2128220530 cites W2059371309 @default.
• W2128220530 cites W2069652470 @default.
• W2128220530 cites W2071881271 @default.
• W2128220530 cites W2077971702 @default.
• W2128220530 cites W2095142337 @default.
• W2128220530 cites W2095234743 @default.
• W2128220530 cites W2096773810 @default.
• W2128220530 cites W2100943227 @default.
• W2128220530 cites W2103043702 @default.
• W2128220530 cites W2106172355 @default.
• W2128220530 cites W2107258432 @default.
• W2128220530 cites W2109283410 @default.
• W2128220530 cites W2117980991 @default.
• W2128220530 cites W2126511201 @default.
• W2128220530 cites W2128635872 @default.
• W2128220530 cites W2128866712 @default.
• W2128220530 cites W2135185526 @default.
• W2128220530 cites W2139191784 @default.
• W2128220530 cites W2143873575 @default.
• W2128220530 cites W2146877877 @default.
• W2128220530 cites W2161071101 @default.
• W2128220530 cites W2161751969 @default.
• W2128220530 cites W2164527218 @default.
• W2128220530 cites W2211610309 @default.
• W2128220530 cites W2337762398 @default.
• W2128220530 cites W2419585095 @default.
• W2128220530 cites W2439233765 @default.
• W2128220530 doi "https://doi.org/10.2337/diabetes.49.8.1288" @default.
• W2128220530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10923627" @default.
• W2128220530 hasPublicationYear "2000" @default.
• W2128220530 type Work @default.
• W2128220530 sameAs 2128220530 @default.
• W2128220530 citedByCount "47" @default.
• W2128220530 countsByYear W21282205302012 @default.
• W2128220530 countsByYear W21282205302013 @default.
• W2128220530 countsByYear W21282205302014 @default.
• W2128220530 countsByYear W21282205302015 @default.
• W2128220530 countsByYear W21282205302016 @default.
• W2128220530 countsByYear W21282205302017 @default.
• W2128220530 countsByYear W21282205302018 @default.
• W2128220530 countsByYear W21282205302019 @default.
• W2128220530 countsByYear W21282205302020 @default.
• W2128220530 countsByYear W21282205302021 @default.
• W2128220530 countsByYear W21282205302023 @default.
• W2128220530 crossrefType "journal-article" @default.
• W2128220530 hasAuthorship W2128220530A5038461805 @default.
• W2128220530 hasAuthorship W2128220530A5040844908 @default.
• W2128220530 hasBestOaLocation W21282205301 @default.
• W2128220530 hasConcept C112446052 @default.
• W2128220530 hasConcept C126322002 @default.
• W2128220530 hasConcept C134018914 @default.
• W2128220530 hasConcept C161573976 @default.
• W2128220530 hasConcept C171089720 @default.
• W2128220530 hasConcept C185592680 @default.

• next