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- W2128238959 endingPage "81" @default.
- W2128238959 startingPage "72" @default.
- W2128238959 abstract "During ontogenesis, haematopoietic stem cells (HSCs) relocate between extra-embryonic and embryonic compartments. Similarly, site-specific homing of HSCs is ongoing during adulthood. With the expanding knowledge of HSC physiology, a new paradigm emerges in which HSCs and haematopoietic progenitor cells (HPCs) migrate to defined microenvironments within the bone marrow (BM) and to 'activated' or 'inducible' niches elsewhere. Here, we summarize current understanding of HSC niche characteristics, and the physiological and pathological mechanisms that guide HSC homing both within the BM and to distant niches in the periphery, promoting new vessel growth in tumours and ischaemia. Recent observations suggest that features of the HSC niche might also be recapitulated in pre-metastatic sites. Clusters of BM-derived HPCs promote invasion of disseminating cancer cells. Clear clinical benefits can be foreseen by modulating HSCs and their microenvironments, in promoting tissue regeneration, and inhibiting tumourigenesis and cancer metastasis." @default.
- W2128238959 created "2016-06-24" @default.
- W2128238959 creator A5021388942 @default.
- W2128238959 creator A5044701800 @default.
- W2128238959 creator A5053302921 @default.
- W2128238959 date "2007-02-01" @default.
- W2128238959 modified "2023-09-26" @default.
- W2128238959 title "Niche-to-niche migration of bone-marrow-derived cells" @default.
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