FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128247024> ?p ?o ?g. }

• W2128247024 endingPage "34020" @default.
• W2128247024 startingPage "34013" @default.
• W2128247024 abstract "Snake presynaptic neurotoxins with phospholipase A(2) activity are potent inducers of paralysis through inhibition of the neuromuscular junction. These neurotoxins were recently shown to induce exocytosis of synaptic vesicles following the production of lysophospholipids and fatty acids and a sustained influx of Ca(2+) from the medium. Here, we show that these toxins are able to penetrate spinal cord motor neurons and cerebellar granule neurons and selectively bind to mitochondria. As a result of this interaction, mitochondria depolarize and undergo a profound shape change from elongated and spaghetti-like to round and swollen. We show that snake presynaptic phospholipase A(2) neurotoxins facilitate opening of the mitochondrial permeability transition pore, an inner membrane high-conductance channel. The relative potency of the snake neurotoxins was similar for the permeability transition pore opening and for the phospholipid hydrolysis activities, suggesting a causal relationship, which is also supported by the effect of phospholipid hydrolysis products, lysophospholipids and fatty acids, on mitochondrial pore opening. These findings contribute to define the cellular events that lead to intoxication of nerve terminals by these snake neurotoxins and suggest that mitochondrial impairment is an important determinant of their toxicity." @default.
• W2128247024 created "2016-06-24" @default.
• W2128247024 creator A5006971623 @default.
• W2128247024 creator A5009191571 @default.
• W2128247024 creator A5022481320 @default.
• W2128247024 creator A5022752763 @default.
• W2128247024 creator A5034304623 @default.
• W2128247024 creator A5082483947 @default.
• W2128247024 creator A5091033956 @default.
• W2128247024 date "2008-12-01" @default.
• W2128247024 modified "2023-10-16" @default.
• W2128247024 title "Snake Phospholipase A2 Neurotoxins Enter Neurons, Bind Specifically to Mitochondria, and Open Their Transition Pores" @default.
• W2128247024 cites W1480829304 @default.
• W2128247024 cites W1486402962 @default.
• W2128247024 cites W1495405792 @default.
• W2128247024 cites W1608814895 @default.
• W2128247024 cites W1973169354 @default.
• W2128247024 cites W1978890100 @default.
• W2128247024 cites W1981331184 @default.
• W2128247024 cites W1981478938 @default.
• W2128247024 cites W1988788901 @default.
• W2128247024 cites W1990925371 @default.
• W2128247024 cites W1998299134 @default.
• W2128247024 cites W2001616870 @default.
• W2128247024 cites W2007483105 @default.
• W2128247024 cites W2009821795 @default.
• W2128247024 cites W2010233410 @default.
• W2128247024 cites W2010582115 @default.
• W2128247024 cites W2023637590 @default.
• W2128247024 cites W2038021366 @default.
• W2128247024 cites W2047010332 @default.
• W2128247024 cites W2055630348 @default.
• W2128247024 cites W2060605524 @default.
• W2128247024 cites W2070066628 @default.
• W2128247024 cites W2073046696 @default.
• W2128247024 cites W2076363630 @default.
• W2128247024 cites W2083901291 @default.
• W2128247024 cites W2086569822 @default.
• W2128247024 cites W2086659716 @default.
• W2128247024 cites W2086692004 @default.
• W2128247024 cites W2088253874 @default.
• W2128247024 cites W2095218706 @default.
• W2128247024 cites W2099718704 @default.
• W2128247024 cites W2109153186 @default.
• W2128247024 cites W2123151328 @default.
• W2128247024 cites W2131625765 @default.
• W2128247024 cites W2142700343 @default.
• W2128247024 cites W2142916237 @default.
• W2128247024 cites W2156254121 @default.
• W2128247024 cites W351537789 @default.
• W2128247024 cites W4296587495 @default.
• W2128247024 cites W6205547 @default.
• W2128247024 doi "https://doi.org/10.1074/jbc.m803243200" @default.
• W2128247024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2662223" @default.
• W2128247024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18809685" @default.
• W2128247024 hasPublicationYear "2008" @default.
• W2128247024 type Work @default.
• W2128247024 sameAs 2128247024 @default.
• W2128247024 citedByCount "83" @default.
• W2128247024 countsByYear W21282470242012 @default.
• W2128247024 countsByYear W21282470242013 @default.
• W2128247024 countsByYear W21282470242014 @default.
• W2128247024 countsByYear W21282470242015 @default.
• W2128247024 countsByYear W21282470242016 @default.
• W2128247024 countsByYear W21282470242017 @default.
• W2128247024 countsByYear W21282470242018 @default.
• W2128247024 countsByYear W21282470242019 @default.
• W2128247024 countsByYear W21282470242020 @default.
• W2128247024 countsByYear W21282470242021 @default.
• W2128247024 countsByYear W21282470242022 @default.
• W2128247024 countsByYear W21282470242023 @default.
• W2128247024 crossrefType "journal-article" @default.
• W2128247024 hasAuthorship W2128247024A5006971623 @default.
• W2128247024 hasAuthorship W2128247024A5009191571 @default.
• W2128247024 hasAuthorship W2128247024A5022481320 @default.
• W2128247024 hasAuthorship W2128247024A5022752763 @default.
• W2128247024 hasAuthorship W2128247024A5034304623 @default.
• W2128247024 hasAuthorship W2128247024A5082483947 @default.
• W2128247024 hasAuthorship W2128247024A5091033956 @default.
• W2128247024 hasBestOaLocation W21282470241 @default.
• W2128247024 hasConcept C12554922 @default.
• W2128247024 hasConcept C130316041 @default.
• W2128247024 hasConcept C13591479 @default.
• W2128247024 hasConcept C148785051 @default.
• W2128247024 hasConcept C181199279 @default.
• W2128247024 hasConcept C185592680 @default.
• W2128247024 hasConcept C190283241 @default.
• W2128247024 hasConcept C2776551241 @default.
• W2128247024 hasConcept C2778918659 @default.
• W2128247024 hasConcept C2780358027 @default.
• W2128247024 hasConcept C28859421 @default.
• W2128247024 hasConcept C31573885 @default.
• W2128247024 hasConcept C4141045 @default.
• W2128247024 hasConcept C41625074 @default.
• W2128247024 hasConcept C55493867 @default.
• W2128247024 hasConcept C86803240 @default.
• W2128247024 hasConcept C95444343 @default.
• W2128247024 hasConceptScore W2128247024C12554922 @default.

• next