FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128271300> ?p ?o ?g. }

• W2128271300 endingPage "1330" @default.
• W2128271300 startingPage "1322" @default.
• W2128271300 abstract "Small-molecule insulin-like growth factor-I receptor (IGF-IR)-specific tyrosine kinase inhibitors have been recently proposed as clinically viable approaches to impair IGF-IR functions. NVP-AEW541 seems one of the most promising agents. In this article, we point out its effects against migration, metastasis, vasculogenicity, and angiogenesis of Ewing's sarcoma cells.In vivo NVP-AEW541 effectiveness was analyzed against TC-71 Ewing's sarcoma growth and bone metastasis after cell inoculation in athymic mice. Activity of the compound against angiogenesis as well as vasculogenesis properties was also considered both in vitro and in xenografts. Serum glucose, urea, transaminase levels, as well as other signs of distress were checked in mice treated with the IGF-IR inhibitor.Significant inhibition of migration, metastasis, vasculogenicity, and angiogenesis was recorded after treatment of Ewing's sarcoma cells with NVP-AEW541. In view of its application and the similarity of insulin receptor and IGF-IR, diabetogenic side effects were considered. We observed a significant decrease of glucose blood serum due to increased glucose uptake at cellular level and an increase in urea concentration. Moreover, an initial weight loss was observed in mice bearing tumors. All these side effects were similarly detected in mice treated with vincristine. After the first days of treatment, all the animals started to grow again.Our results globally reinforce the idea that IGF-IR inhibitor NVP-AEW541 could have a role in future combined therapies and suggest to pursue a thorough molecular analysis of the metabolic activity of IGF-IR to avoid possible side effects of these inhibitors." @default.
• W2128271300 created "2016-06-24" @default.
• W2128271300 creator A5006321055 @default.
• W2128271300 creator A5013677367 @default.
• W2128271300 creator A5015636061 @default.
• W2128271300 creator A5022563430 @default.
• W2128271300 creator A5025533934 @default.
• W2128271300 creator A5043283322 @default.
• W2128271300 creator A5047346473 @default.
• W2128271300 creator A5058616554 @default.
• W2128271300 creator A5083948167 @default.
• W2128271300 creator A5086604304 @default.
• W2128271300 creator A5089863595 @default.
• W2128271300 date "2007-02-15" @default.
• W2128271300 modified "2023-10-18" @default.
• W2128271300 title "Preclinical <i>In vivo</i> Study of New Insulin-Like Growth Factor-I Receptor–Specific Inhibitor in Ewing's Sarcoma" @default.
• W2128271300 cites W1933773958 @default.
• W2128271300 cites W1966872309 @default.
• W2128271300 cites W1978922759 @default.
• W2128271300 cites W1982786052 @default.
• W2128271300 cites W1989657978 @default.
• W2128271300 cites W1990430867 @default.
• W2128271300 cites W1991414324 @default.
• W2128271300 cites W1999030960 @default.
• W2128271300 cites W2004510380 @default.
• W2128271300 cites W2011028805 @default.
• W2128271300 cites W2015524046 @default.
• W2128271300 cites W2018987187 @default.
• W2128271300 cites W2021942056 @default.
• W2128271300 cites W2038819621 @default.
• W2128271300 cites W2054016503 @default.
• W2128271300 cites W2060569905 @default.
• W2128271300 cites W2061054148 @default.
• W2128271300 cites W2071693303 @default.
• W2128271300 cites W2074111028 @default.
• W2128271300 cites W2093221289 @default.
• W2128271300 cites W2098544382 @default.
• W2128271300 cites W2102820712 @default.
• W2128271300 cites W2107989095 @default.
• W2128271300 cites W2114321011 @default.
• W2128271300 cites W2116354931 @default.
• W2128271300 cites W2121577790 @default.
• W2128271300 cites W2128412799 @default.
• W2128271300 cites W2130288179 @default.
• W2128271300 cites W2171347556 @default.
• W2128271300 cites W2203078078 @default.
• W2128271300 cites W2410005574 @default.
• W2128271300 cites W3140002906 @default.
• W2128271300 doi "https://doi.org/10.1158/1078-0432.ccr-06-1518" @default.
• W2128271300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17317844" @default.
• W2128271300 hasPublicationYear "2007" @default.
• W2128271300 type Work @default.
• W2128271300 sameAs 2128271300 @default.
• W2128271300 citedByCount "126" @default.
• W2128271300 countsByYear W21282713002012 @default.
• W2128271300 countsByYear W21282713002013 @default.
• W2128271300 countsByYear W21282713002014 @default.
• W2128271300 countsByYear W21282713002015 @default.
• W2128271300 countsByYear W21282713002016 @default.
• W2128271300 countsByYear W21282713002017 @default.
• W2128271300 countsByYear W21282713002018 @default.
• W2128271300 countsByYear W21282713002019 @default.
• W2128271300 countsByYear W21282713002020 @default.
• W2128271300 countsByYear W21282713002021 @default.
• W2128271300 countsByYear W21282713002022 @default.
• W2128271300 countsByYear W21282713002023 @default.
• W2128271300 crossrefType "journal-article" @default.
• W2128271300 hasAuthorship W2128271300A5006321055 @default.
• W2128271300 hasAuthorship W2128271300A5013677367 @default.
• W2128271300 hasAuthorship W2128271300A5015636061 @default.
• W2128271300 hasAuthorship W2128271300A5022563430 @default.
• W2128271300 hasAuthorship W2128271300A5025533934 @default.
• W2128271300 hasAuthorship W2128271300A5043283322 @default.
• W2128271300 hasAuthorship W2128271300A5047346473 @default.
• W2128271300 hasAuthorship W2128271300A5058616554 @default.
• W2128271300 hasAuthorship W2128271300A5083948167 @default.
• W2128271300 hasAuthorship W2128271300A5086604304 @default.
• W2128271300 hasAuthorship W2128271300A5089863595 @default.
• W2128271300 hasBestOaLocation W21282713001 @default.
• W2128271300 hasConcept C112446052 @default.
• W2128271300 hasConcept C121608353 @default.
• W2128271300 hasConcept C126322002 @default.
• W2128271300 hasConcept C134018914 @default.
• W2128271300 hasConcept C142724271 @default.
• W2128271300 hasConcept C150903083 @default.
• W2128271300 hasConcept C170493617 @default.
• W2128271300 hasConcept C207001950 @default.
• W2128271300 hasConcept C2775960820 @default.
• W2128271300 hasConcept C2777391703 @default.
• W2128271300 hasConcept C2778256501 @default.
• W2128271300 hasConcept C2779013556 @default.
• W2128271300 hasConcept C2779306644 @default.
• W2128271300 hasConcept C2780394083 @default.
• W2128271300 hasConcept C2780689927 @default.
• W2128271300 hasConcept C502942594 @default.
• W2128271300 hasConcept C71924100 @default.
• W2128271300 hasConcept C86803240 @default.
• W2128271300 hasConceptScore W2128271300C112446052 @default.

• next