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- W2128300032 endingPage "55" @default.
- W2128300032 startingPage "25" @default.
- W2128300032 abstract "Synapses are highly specialized intercellular junctions that mediate the transmission of information between axons and target cells. A fundamental property of synapses is their ability to modify the efficacy of synaptic communication through various forms of synaptic plasticity. Recent developments in imaging techniques have revealed that synapses exhibit a high degree of morphological plasticity under basal conditions and also in response to neuronal activity that induces alterations in synaptic strength. The underlying molecular basis for this morphological plasticity has attracted much attention, yet its functional significance to the mechanisms of synaptic transmission and synaptic plasticity remains elusive. These morphological changes ultimately require the dynamic actin cytoskeleton, which is the major structural component of synapses. Delineating the physiological roles of the actin cytoskeleton in supporting synaptic transmission and synaptic plasticity, therefore, paves the way for gaining molecular insights into when and how synaptic machineries couple synapse form and function." @default.
- W2128300032 created "2016-06-24" @default.
- W2128300032 creator A5036776345 @default.
- W2128300032 creator A5073132799 @default.
- W2128300032 date "2005-07-21" @default.
- W2128300032 modified "2023-10-16" @default.
- W2128300032 title "THE ACTIN CYTOSKELETON: Integrating Form and Function at the Synapse" @default.
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