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- W2128311633 abstract "The majority of cases of hemolyticuremic syndrome and a smaller proportion of cases of thrombotic thrombocytopenic purpura have recently been shown to result from a toxin produced by enteric bacteria, referred to as verotoxin, or Shiga-like toxin. The predominant toxin-producing bacterial strain in North America is E. coli 0157:H7, which causes hemorrhagic colitis in humans after ingestion of contaminated meat. The toxin is believed to gain entry to the circulation from the bowel wall; it then binds to specific glycolipid receptors abundant on renal vascular endothelial cells. The toxin inactivates ribosomes inside the cells, thereby killing them and producing the clinical manifestations of hemolytic-uremic syndrome. Recognition of the etiology of hemolytic-uremic syndrome may lead to better prospects for prevention and treatment." @default.
- W2128311633 created "2016-06-24" @default.
- W2128311633 creator A5043382019 @default.
- W2128311633 date "1993-12-01" @default.
- W2128311633 modified "2023-09-29" @default.
- W2128311633 title "Southwestern Internal Medicine Conference: Shiga-like Toxins in Hemolytic-Uremic Syndrome and Thrombotic Thrombocytopenic Purpura" @default.
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- W2128311633 doi "https://doi.org/10.1097/00000441-199312000-00009" @default.
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