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• W2128315537 abstract "Summary The class 1A aldehyde dehydrogenase ( ALDH 1A) subfamily of genes encode enzymes that function at the apex of the retinoic acid ( RA ) signalling pathway. We detected aberrant expression of ALDH 1A genes, particularly ALDH 1A2 , in a majority (72%) of primary paediatric T cell acute lymphoblastic leukaemia (T‐ ALL ) specimens. ALDH 1A expression was almost exclusive to T‐lineage, but not B‐lineage, ALL . To determine whether ALDH 1A expression may have relevance to T‐ ALL cell growth and survival, the effect of inhibiting ALDH 1A function was measured on a panel of human ALL cell lines. This revealed that T‐ ALL proliferation had a higher sensitivity to modulation of ALDH 1A activity and RA signalling as compared to ALL cell lines of B‐lineage. Consistent with these findings, the genes most highly correlated with ALDH 1A2 expression were involved in cell proliferation and apoptosis. Evidence that such genes may be targets of regulation via RA signalling initiated by ALDH 1A activity was provided by the TNFRSF 10B gene , encoding the apoptotic death receptor TNFRSF 10B (also termed TRAIL ‐R2), which negatively correlated with ALDH 1A2 and showed elevated transcription following treatment of T‐ ALL cell lines with the ALDH 1A inhibitor citral (3,7‐dimethyl‐2,6‐octadienal). These data indicate that ALDH 1A expression is a common event in T‐ ALL and supports a role for these enzymes in the pathobiology of this disease." @default.
• W2128315537 created "2016-06-24" @default.
• W2128315537 creator A5012291376 @default.
• W2128315537 creator A5031588652 @default.
• W2128315537 creator A5047693522 @default.
• W2128315537 creator A5055122981 @default.
• W2128315537 creator A5064740952 @default.
• W2128315537 date "2014-09-11" @default.
• W2128315537 modified "2023-09-27" @default.
• W2128315537 title "Aberrant expression of aldehyde dehydrogenase 1A (ALDH1A) subfamily genes in acute lymphoblastic leukaemia is a common feature of T-lineage tumours" @default.
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• W2128315537 doi "https://doi.org/10.1111/bjh.13120" @default.
• W2128315537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25208926" @default.
• W2128315537 hasPublicationYear "2014" @default.
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