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W2128321922 startingPage "2715" @default.
W2128321922 abstract "Exposure to microgravity results in cardiovascular deconditioning, and cerebrovascular oxidative stress injury has been suggested to occur. To elucidate the mechanism for this condition, we investigated whether simulated microgravity induces mitochondrial dysfunction in rat arteries. Four-week hindlimb unweighting (HU) was used to simulate microgravity in rats. Mitochondrial reactive oxygen species (ROS), mitochondrial membrane potential (Δψm), mitochondrial permeability transition pore (mPTP) opening, mitochondrial respiratory control ratio (RCR), MnSOD/GPx activity and expression, and mitochondrial malondialdehyde (MDA) were examined in rat cerebral and mesenteric VSMCs. Compared with the control rats, mitochondrial ROS levels, mPTP opening, and MDA content increased significantly (P< 0.001, P<0.01, and P<0.01, respectively), Δψm, RCR, MnSOD/GPx activity (P<0.001 for Δψm and RCR; P<0.05 for MnSOD; and P< 0.001 for GPx activity) and protein abundance of mitochondrial MnSOD/GPx-1 decreased (P<0.001 for MnSOD and GPx-1) in HU rat cerebral but not mesenteric arteries. Chronic treatment with NADPH oxidase inhibitor apocynin and mitochondria-targeted antioxidant mitoTempol promoted recovery of mitochondrial function in HU rat cerebral arteries, but exerted no effects on HU rat mesenteric arteries. Therefore, simulated microgravity resulted in cerebrovascular mitochondrial dysfunction, and crosstalk between NADPH oxidase and mitochondria participated in the process.—Zhang, R., Ran, H.-H., Cai, L.-L, Zhu, L., Sun, J.-F., Peng, L., Liu, X.-J., Zhang, L.-N., Fang, Z., Fan, Y.-Y., Cui, G. Simulated microgravity induced mitochondrial dysfunction in rat cerebral arteries. FASEB J. 28, 2715–2724 (2014). www.fasebj.org" @default.
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W2128321922 date "2014-03-06" @default.
W2128321922 modified "2023-10-11" @default.
W2128321922 title "Simulated microgravity‐induced mitochondrial dysfunction in rat cerebral arteries" @default.
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W2128321922 doi "https://doi.org/10.1096/fj.13-245654" @default.
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