Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128347961> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2128347961 endingPage "1538" @default.
- W2128347961 startingPage "1535" @default.
- W2128347961 abstract "p -Cresol (4-methylphenol; 108 Da) is a protein-bound solute retained within the body in renal failure (1). p -Cresol is of interest because it has several toxic effects in vitro (2)(3)(4)(5)(6) and clinical correlates have been demonstrated (7)(8). In the absence of external exposure (9), p -cresol originates uniquely from bacterial tyrosine fermentation in the large intestine (10). During passage through the colonic mucosa and liver, it is detoxified by conjugation processes (sulfation and glucuronidation) (11)(12)(13). Thus, one might expect to find p -cresylsulfate and p -cresylglucuronide in the serum, but reports on conjugated p -cresol in renal failure patients are scarce (14)(15)(16). Most techniques to deproteinize serum samples (e.g., heat and acidification) may also partially hydrolyze sulfate esters and glucuronide bonds. Hence, the “total” (i.e., protein-bound and unbound) and “unbound” p -cresol reported in most studies probably reflect both unconjugated and (part of the) conjugated forms of the solute (17)(18)(19)(20)(21). We determined the extent of desulfation and deglucuronidation by deproteinization with heat and acid followed by gas chromatographic–mass spectrometric (GC-MS) analysis (19) with p -nitrophenylglucuronide and p -nitrophenylsulfate as model substrates. We also calculated exact amounts of unconjugated p -cresol, p -cresylsulfate, and p -cresylglucuronide in serum of hemodialysis patients and healthy controls.Percentage desulfation and deglucuronidation by different methods (see below) was determined for random serum samples. Further analyses were performed on 9 serum pools from hemodialysis patients [n = 86; 49 male; mean (SD) age, 69.8 (1.5) years] and 5 serum pools from healthy controls [n = 29; 10 male; 31.0 (1.4) years; creatinine clearance, 87.1 (1.4) mL · min−1 · (1.73 m2)−1]. Serum pools were …" @default.
- W2128347961 created "2016-06-24" @default.
- W2128347961 creator A5007986643 @default.
- W2128347961 creator A5042026584 @default.
- W2128347961 creator A5047410548 @default.
- W2128347961 creator A5080260698 @default.
- W2128347961 creator A5083782401 @default.
- W2128347961 date "2005-08-01" @default.
- W2128347961 modified "2023-10-12" @default.
- W2128347961 title "Gas Chromatographic–Mass Spectrometric Analysis for Measurement of p-Cresol and Its Conjugated Metabolites in Uremic and Normal Serum" @default.
- W2128347961 cites W1564923084 @default.
- W2128347961 cites W1899545080 @default.
- W2128347961 cites W1900897748 @default.
- W2128347961 cites W1973181684 @default.
- W2128347961 cites W1976479075 @default.
- W2128347961 cites W1982298907 @default.
- W2128347961 cites W1985972964 @default.
- W2128347961 cites W1989050935 @default.
- W2128347961 cites W1995804219 @default.
- W2128347961 cites W2004230365 @default.
- W2128347961 cites W2017365602 @default.
- W2128347961 cites W2022391402 @default.
- W2128347961 cites W2065906111 @default.
- W2128347961 cites W2076072930 @default.
- W2128347961 cites W2089011161 @default.
- W2128347961 cites W2112299890 @default.
- W2128347961 cites W2116576035 @default.
- W2128347961 cites W2122231873 @default.
- W2128347961 cites W2136833906 @default.
- W2128347961 cites W2144661108 @default.
- W2128347961 cites W2148081289 @default.
- W2128347961 cites W2372845107 @default.
- W2128347961 doi "https://doi.org/10.1373/clinchem.2005.050781" @default.
- W2128347961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16040852" @default.
- W2128347961 hasPublicationYear "2005" @default.
- W2128347961 type Work @default.
- W2128347961 sameAs 2128347961 @default.
- W2128347961 citedByCount "167" @default.
- W2128347961 countsByYear W21283479612012 @default.
- W2128347961 countsByYear W21283479612013 @default.
- W2128347961 countsByYear W21283479612014 @default.
- W2128347961 countsByYear W21283479612015 @default.
- W2128347961 countsByYear W21283479612016 @default.
- W2128347961 countsByYear W21283479612017 @default.
- W2128347961 countsByYear W21283479612018 @default.
- W2128347961 countsByYear W21283479612019 @default.
- W2128347961 countsByYear W21283479612020 @default.
- W2128347961 countsByYear W21283479612021 @default.
- W2128347961 countsByYear W21283479612022 @default.
- W2128347961 countsByYear W21283479612023 @default.
- W2128347961 crossrefType "journal-article" @default.
- W2128347961 hasAuthorship W2128347961A5007986643 @default.
- W2128347961 hasAuthorship W2128347961A5042026584 @default.
- W2128347961 hasAuthorship W2128347961A5047410548 @default.
- W2128347961 hasAuthorship W2128347961A5080260698 @default.
- W2128347961 hasAuthorship W2128347961A5083782401 @default.
- W2128347961 hasBestOaLocation W21283479611 @default.
- W2128347961 hasConcept C112613896 @default.
- W2128347961 hasConcept C123460561 @default.
- W2128347961 hasConcept C178790620 @default.
- W2128347961 hasConcept C185592680 @default.
- W2128347961 hasConcept C2778013464 @default.
- W2128347961 hasConcept C43617362 @default.
- W2128347961 hasConcept C521977710 @default.
- W2128347961 hasConceptScore W2128347961C112613896 @default.
- W2128347961 hasConceptScore W2128347961C123460561 @default.
- W2128347961 hasConceptScore W2128347961C178790620 @default.
- W2128347961 hasConceptScore W2128347961C185592680 @default.
- W2128347961 hasConceptScore W2128347961C2778013464 @default.
- W2128347961 hasConceptScore W2128347961C43617362 @default.
- W2128347961 hasConceptScore W2128347961C521977710 @default.
- W2128347961 hasIssue "8" @default.
- W2128347961 hasLocation W21283479611 @default.
- W2128347961 hasLocation W21283479612 @default.
- W2128347961 hasLocation W21283479613 @default.
- W2128347961 hasOpenAccess W2128347961 @default.
- W2128347961 hasPrimaryLocation W21283479611 @default.
- W2128347961 hasRelatedWork W1986049138 @default.
- W2128347961 hasRelatedWork W2007164458 @default.
- W2128347961 hasRelatedWork W2008354382 @default.
- W2128347961 hasRelatedWork W2022224243 @default.
- W2128347961 hasRelatedWork W2075198971 @default.
- W2128347961 hasRelatedWork W2346698954 @default.
- W2128347961 hasRelatedWork W2402394151 @default.
- W2128347961 hasRelatedWork W2951381597 @default.
- W2128347961 hasRelatedWork W2952305790 @default.
- W2128347961 hasRelatedWork W2953180194 @default.
- W2128347961 hasVolume "51" @default.
- W2128347961 isParatext "false" @default.
- W2128347961 isRetracted "false" @default.
- W2128347961 magId "2128347961" @default.
- W2128347961 workType "article" @default.