FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128387393> ?p ?o ?g. }

• W2128387393 endingPage "12" @default.
• W2128387393 startingPage "12" @default.
• W2128387393 abstract "The classification of pain into nociceptive and neuropathic pain is based on characteristic symptoms and different pathophysiological mechanisms. In a recent investigation, we found a disrupted TH17/Treg balance in patients suffering from chronic unspecific low back pain (CLBP). These patients did not show any signs of neuropathy. There is evidence for a considerable impact of the immune system also in neuropathic pain. However, the role of the adaptive immune system is still unclear. In the present study, we investigated systemic T-cell subset responses and T-cell related cytokine profiles in patients with chronic neuropathic pain.We analyzed T-cell subsets, mRNA expression and T-cell-related cytokine profiles in 26 patients suffering from neuropathic pain in comparison to 26 healthy controls. Using multicolor flow cytometry (FACS), we quantified the number of T helper cells 1 (TH1), TH2, TH17 and regulatory T-cells (Tregs). Forkhead-Box-Protein 3 (FoxP3), Transforming growth factor-β (TGF-β) and RAR-related orphan receptor-γT (ROR-γT) mRNA expression was determined by quantitative real-time PCR (qPCR) and levels of pain-related cytokines were measured by Human Cytokine Multiplex Immunoassay (Macrophage inflammatory protein-1α (MIP-1α), Tumor necrosis factor-α (TNF-α), Interferon-γ (IFN-γ), Interleukin (IL) -4, IL-6, IL-10, IL-17, and IL-23).We found a TH17/Treg imbalance with significantly increased anti-inflammatory Tregs and decreased pro-inflammatory TH17 cells in patients with neuropathic pain as compared to healthy controls. These results were confirmed on mRNA level: Treg-related FoxP3 and TGF-β mRNA expression was elevated, whereas expression of TH17-related RORγT was reduced. Cytokine analyses revealed only marginal changes.Our investigation revealed a clear shift of T-cell subsets towards anti-inflammation in patients with neuropathic pain. Interestingly, this is quite similar to our previous findings in CLBP patients, but even more pronounced. Therefore, it remains to be elucidated in future investigations whether the immune changes represent an underlying pathophysiological mechanism or an epiphenomenon induced by ongoing pain and stress.Trial registration number: DRKS00005954." @default.
• W2128387393 created "2016-06-24" @default.
• W2128387393 creator A5008928704 @default.
• W2128387393 creator A5010128822 @default.
• W2128387393 creator A5031876269 @default.
• W2128387393 creator A5049075068 @default.
• W2128387393 creator A5050502610 @default.
• W2128387393 creator A5088183628 @default.
• W2128387393 date "2015-01-01" @default.
• W2128387393 modified "2023-10-08" @default.
• W2128387393 title "Anti-inflammatory T-cell shift in neuropathic pain" @default.
• W2128387393 cites W1496226934 @default.
• W2128387393 cites W1520207918 @default.
• W2128387393 cites W1968618759 @default.
• W2128387393 cites W1969851799 @default.
• W2128387393 cites W1970202520 @default.
• W2128387393 cites W1975134593 @default.
• W2128387393 cites W1981912417 @default.
• W2128387393 cites W1984144008 @default.
• W2128387393 cites W1988790345 @default.
• W2128387393 cites W1995526849 @default.
• W2128387393 cites W1997343220 @default.
• W2128387393 cites W2014313724 @default.
• W2128387393 cites W2021132159 @default.
• W2128387393 cites W2022052400 @default.
• W2128387393 cites W2023525414 @default.
• W2128387393 cites W2033417908 @default.
• W2128387393 cites W2034040607 @default.
• W2128387393 cites W2061678130 @default.
• W2128387393 cites W2068898187 @default.
• W2128387393 cites W2072853625 @default.
• W2128387393 cites W2077002902 @default.
• W2128387393 cites W2077506348 @default.
• W2128387393 cites W2078439148 @default.
• W2128387393 cites W2079224508 @default.
• W2128387393 cites W2084255719 @default.
• W2128387393 cites W2106991289 @default.
• W2128387393 cites W2107337543 @default.
• W2128387393 cites W2111964682 @default.
• W2128387393 cites W2120321156 @default.
• W2128387393 cites W2126283897 @default.
• W2128387393 cites W2127298360 @default.
• W2128387393 cites W2139058687 @default.
• W2128387393 cites W2141989396 @default.
• W2128387393 cites W2154693681 @default.
• W2128387393 cites W2164513741 @default.
• W2128387393 cites W2164864581 @default.
• W2128387393 cites W2370687088 @default.
• W2128387393 cites W3192794816 @default.
• W2128387393 cites W72659141 @default.
• W2128387393 doi "https://doi.org/10.1186/s12974-014-0225-0" @default.
• W2128387393 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4308022" @default.
• W2128387393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25608762" @default.
• W2128387393 hasPublicationYear "2015" @default.
• W2128387393 type Work @default.
• W2128387393 sameAs 2128387393 @default.
• W2128387393 citedByCount "55" @default.
• W2128387393 countsByYear W21283873932015 @default.
• W2128387393 countsByYear W21283873932016 @default.
• W2128387393 countsByYear W21283873932017 @default.
• W2128387393 countsByYear W21283873932018 @default.
• W2128387393 countsByYear W21283873932019 @default.
• W2128387393 countsByYear W21283873932020 @default.
• W2128387393 countsByYear W21283873932021 @default.
• W2128387393 countsByYear W21283873932022 @default.
• W2128387393 countsByYear W21283873932023 @default.
• W2128387393 crossrefType "journal-article" @default.
• W2128387393 hasAuthorship W2128387393A5008928704 @default.
• W2128387393 hasAuthorship W2128387393A5010128822 @default.
• W2128387393 hasAuthorship W2128387393A5031876269 @default.
• W2128387393 hasAuthorship W2128387393A5049075068 @default.
• W2128387393 hasAuthorship W2128387393A5050502610 @default.
• W2128387393 hasAuthorship W2128387393A5088183628 @default.
• W2128387393 hasBestOaLocation W21283873931 @default.
• W2128387393 hasConcept C17991360 @default.
• W2128387393 hasConcept C1862650 @default.
• W2128387393 hasConcept C203014093 @default.
• W2128387393 hasConcept C2776090121 @default.
• W2128387393 hasConcept C2776914184 @default.
• W2128387393 hasConcept C2777107010 @default.
• W2128387393 hasConcept C2778296632 @default.
• W2128387393 hasConcept C2778690821 @default.
• W2128387393 hasConcept C2779727006 @default.
• W2128387393 hasConcept C2781118164 @default.
• W2128387393 hasConcept C71924100 @default.
• W2128387393 hasConcept C74737994 @default.
• W2128387393 hasConcept C79484868 @default.
• W2128387393 hasConcept C8891405 @default.
• W2128387393 hasConcept C98274493 @default.
• W2128387393 hasConceptScore W2128387393C17991360 @default.
• W2128387393 hasConceptScore W2128387393C1862650 @default.
• W2128387393 hasConceptScore W2128387393C203014093 @default.
• W2128387393 hasConceptScore W2128387393C2776090121 @default.
• W2128387393 hasConceptScore W2128387393C2776914184 @default.
• W2128387393 hasConceptScore W2128387393C2777107010 @default.
• W2128387393 hasConceptScore W2128387393C2778296632 @default.
• W2128387393 hasConceptScore W2128387393C2778690821 @default.
• W2128387393 hasConceptScore W2128387393C2779727006 @default.

• next