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• W2128391446 abstract "Background: Yes-associated protein 1 (YAP1) is an effector of the Hippo pathway, which is critical for regulating organ size and cell proliferation in mammals. To investigate the prognostic value of YAP1 in gastric cancer (GC), we assessed its expression in tumors from patients. Materials and Methods: We examined the nuclear expression of the YAP1 protein in 223 cases of GC, particularly of stage II and III disease, using immunohistochemistry. Results: Positive nuclear expression of YAP1 was detected in 27.4% (61/223) of total GCs, 29.1% (34/117) of the intestinal-type GCs (IGC) and 25.5% (27/106) of the diffuse-type GCs (DGC). In the IGC group, we found that the overall survival rate among patients with YAP1 nuclear expression-positive tumors was lower than that in the expression-negative group (p=0.021). Cox multivariate analysis revealed that the nuclear expression of YAP1 was an independent prognosticator of IGC (p=0.018). Conclusion: The nuclear overexpression of YAP1 is an independent biomarker for poor survival, especially for patients with intestinal-type gastric cancer. Yes-associated protein 1 (YAP1), a 65-kDa proline-rich phosphoprotein, was initially identified due to its interaction with the SH3 domain of the c-Yes tyrosine kinase (1). Subsequent studies revealed that YAP1 is a transcriptional co- activator interacting with PPXY-motif-containing transcription factors and TEAD-family transcription factors (2-4). YAP1 is considered a nuclear effector of the Hippo pathway (5, 6). The Hippo pathway, a vital regulator of organ size control and tumorigenesis, was initially identified by mosaic screening in Drosophila melanogaster (7-11). Components of the Hippo pathway are highly conserved from Drosophila to mammals, including Mst1/2 (hippo homolog), Sav1 (salvador homolog), Lats1/2 (warts homolog), Mob1 (Mats homolog), Yap1 and Taz (Yorkie homolog) (6, 12, 13). The Hippo pathway kinase cascade phosphorylates YAP1 and induces sequestration of YAP1 in the cytoplasm, with the binding of YAP1 to 14-3-3, thus inhibiting its transcriptional activity (5, 14, 15)." @default.
• W2128391446 created "2016-06-24" @default.
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• W2128391446 date "2012-09-01" @default.
• W2128391446 modified "2023-09-23" @default.
• W2128391446 title "Nuclear Expression of Yes-associated Protein 1 Correlates with Poor Prognosis in Intestinal Type Gastric Cancer" @default.
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