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- W2128423101 abstract "The compartmental effects of angiotensin II (AII) and arginine-vasopressin (AVP) on renal prostaglandin (PG) formation were studied in the isolated perfused kidney of the rabbit by superfusion bioassay of venous and ureteral effluents (VE and UE) and radioimmunoassay (RIA). Comparable results were obtained with either bioassay or RIA when used to quantitate renal PG release. The effects on PG release into the VE were similar for AII and AVP, as were their pressor reponses. However, their effects on PG release into the UE differed markedly. AII resulted in a 6-fold greater urinary efflux than venous of bioassayable PGs, whereas AVP-induced PG release into UE was slightly less than PG efflux into the VE at all doses of the peptide. The profile of released PGs varied according to the sampling source (VE or UE). Moreover, each peptide released a similar profile of PGs at all doses, i.e. UE PGE2 > PGF2α > 6-keto PGF1α; VE PGE2 > 6-keto PGF1α > PGF2α (TxB2 was not detected in either effluent). Thus, renal vascular PG release is similar for the vasoactive peptides, AII and AVP, whereas the urinary efflux of PGs is considerably greater in response to AII." @default.
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- W2128423101 date "1986-01-01" @default.
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- W2128423101 title "Compartmental prostaglandin release by angiotensin II and arginine-vasopressin in rabbit isolated perfused kidneys" @default.
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- W2128423101 doi "https://doi.org/10.1016/0014-2999(86)90637-0" @default.
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