FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128425744> ?p ?o ?g. }

• W2128425744 endingPage "803" @default.
• W2128425744 startingPage "795" @default.
• W2128425744 abstract "Meiotic maturation in oocytes is a prolonged process that is unique because of cell cycle arrests at prophase of meiosis I (MI) and at metaphase of meiosis II (MII). Fluctuations in cyclin-dependent kinase 1 (CDK1/CDC2A) activity govern meiotic progression, yet little is known about how these fluctuations are achieved. CDC14 is a highly conserved dual-specificity phosphatase that counteracts the function of proteins phosphorylated by CDK. Mammals contain two CDC14 homologs, CDC14A and CDC14B. We report that CDC14B localizes with the meiotic spindle in mouse oocytes, and (unlike somatic cells) it does not localize in the nucleolus. Oocytes that overexpress CDC14B are significantly delayed in resuming meiosis and fail to progress to MII, whereas oocytes depleted of CDC14B spontaneously resume meiosis under conditions that normally inhibit meiotic resumption. Depletion of FZR1 (CDH1), a regulatory subunit of the anaphase-promoting complex/cyclosome that targets cyclin B1 (CCNB1) for ubiquitin-mediated proteolysis, partially restores normal timing of meiotic resumption in oocytes with excess CDC14B. These studies also reveal that experimentally altering CDC14B levels generates eggs with abnormal spindles and with chromosome alignment perturbations. Our data indicate that CDC14B is a negative regulator of meiotic resumption and may regulate MI in mouse oocytes." @default.
• W2128425744 created "2016-06-24" @default.
• W2128425744 creator A5002886426 @default.
• W2128425744 creator A5061586848 @default.
• W2128425744 date "2009-04-01" @default.
• W2128425744 modified "2023-10-14" @default.
• W2128425744 title "CDC14B Acts Through FZR1 (CDH1) to Prevent Meiotic Maturation of Mouse Oocytes1" @default.
• W2128425744 cites W1522784058 @default.
• W2128425744 cites W1963937857 @default.
• W2128425744 cites W1963951796 @default.
• W2128425744 cites W1967163876 @default.
• W2128425744 cites W1969030895 @default.
• W2128425744 cites W1971883493 @default.
• W2128425744 cites W1978570830 @default.
• W2128425744 cites W1978592193 @default.
• W2128425744 cites W1987767376 @default.
• W2128425744 cites W1988084073 @default.
• W2128425744 cites W2008187459 @default.
• W2128425744 cites W2009445275 @default.
• W2128425744 cites W2012455156 @default.
• W2128425744 cites W2012628447 @default.
• W2128425744 cites W2023792327 @default.
• W2128425744 cites W2025425793 @default.
• W2128425744 cites W2027540736 @default.
• W2128425744 cites W2029283724 @default.
• W2128425744 cites W2048690485 @default.
• W2128425744 cites W2058954610 @default.
• W2128425744 cites W2061027592 @default.
• W2128425744 cites W2062077169 @default.
• W2128425744 cites W2063855981 @default.
• W2128425744 cites W2065305930 @default.
• W2128425744 cites W2065876736 @default.
• W2128425744 cites W2068022037 @default.
• W2128425744 cites W2078826636 @default.
• W2128425744 cites W2079921190 @default.
• W2128425744 cites W2080252696 @default.
• W2128425744 cites W2110993745 @default.
• W2128425744 cites W2112854488 @default.
• W2128425744 cites W2132592231 @default.
• W2128425744 cites W2145683104 @default.
• W2128425744 cites W2149730011 @default.
• W2128425744 cites W2150809319 @default.
• W2128425744 cites W2152604527 @default.
• W2128425744 cites W2154019163 @default.
• W2128425744 cites W2156128097 @default.
• W2128425744 cites W2162606553 @default.
• W2128425744 cites W2164366687 @default.
• W2128425744 cites W4211135707 @default.
• W2128425744 doi "https://doi.org/10.1095/biolreprod.108.074906" @default.
• W2128425744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2804832" @default.
• W2128425744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19129509" @default.
• W2128425744 hasPublicationYear "2009" @default.
• W2128425744 type Work @default.
• W2128425744 sameAs 2128425744 @default.
• W2128425744 citedByCount "59" @default.
• W2128425744 countsByYear W21284257442012 @default.
• W2128425744 countsByYear W21284257442013 @default.
• W2128425744 countsByYear W21284257442014 @default.
• W2128425744 countsByYear W21284257442015 @default.
• W2128425744 countsByYear W21284257442016 @default.
• W2128425744 countsByYear W21284257442018 @default.
• W2128425744 countsByYear W21284257442019 @default.
• W2128425744 countsByYear W21284257442020 @default.
• W2128425744 countsByYear W21284257442022 @default.
• W2128425744 countsByYear W21284257442023 @default.
• W2128425744 crossrefType "journal-article" @default.
• W2128425744 hasAuthorship W2128425744A5002886426 @default.
• W2128425744 hasAuthorship W2128425744A5061586848 @default.
• W2128425744 hasBestOaLocation W21284257441 @default.
• W2128425744 hasConcept C104317684 @default.
• W2128425744 hasConcept C120089663 @default.
• W2128425744 hasConcept C120504264 @default.
• W2128425744 hasConcept C148196450 @default.
• W2128425744 hasConcept C1491633281 @default.
• W2128425744 hasConcept C196843134 @default.
• W2128425744 hasConcept C2776690073 @default.
• W2128425744 hasConcept C2778437423 @default.
• W2128425744 hasConcept C2910992960 @default.
• W2128425744 hasConcept C29537977 @default.
• W2128425744 hasConcept C30481170 @default.
• W2128425744 hasConcept C45413362 @default.
• W2128425744 hasConcept C54355233 @default.
• W2128425744 hasConcept C64894306 @default.
• W2128425744 hasConcept C70278784 @default.
• W2128425744 hasConcept C86803240 @default.
• W2128425744 hasConcept C95444343 @default.
• W2128425744 hasConcept C9743823 @default.
• W2128425744 hasConceptScore W2128425744C104317684 @default.
• W2128425744 hasConceptScore W2128425744C120089663 @default.
• W2128425744 hasConceptScore W2128425744C120504264 @default.
• W2128425744 hasConceptScore W2128425744C148196450 @default.
• W2128425744 hasConceptScore W2128425744C1491633281 @default.
• W2128425744 hasConceptScore W2128425744C196843134 @default.
• W2128425744 hasConceptScore W2128425744C2776690073 @default.
• W2128425744 hasConceptScore W2128425744C2778437423 @default.
• W2128425744 hasConceptScore W2128425744C2910992960 @default.
• W2128425744 hasConceptScore W2128425744C29537977 @default.
• W2128425744 hasConceptScore W2128425744C30481170 @default.

• next