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- W2128446478 abstract "Pathogenesis-related 10 (PR-10) proteins are involved in many aspects of plant biology but their molecular function is still unclear. They are related by sequence and structural homology to mammalian lipid transport and plant abscisic acid receptor proteins and are predicted to have cavities for ligand binding. Recently, three new members of the PR-10 family, the Fra a proteins, have been identified in strawberry, where they are required for the activity of the flavonoid biosynthesis pathway, which is essential for the development of color and flavor in fruits. Here, we show that Fra a proteins bind natural flavonoids with different selectivity and affinities in the low μm range. The structural analysis of Fra a 1 E and a Fra a 3-catechin complex indicates that loops L3, L5, and L7 surrounding the ligand-binding cavity show significant flexibility in the apo forms but close over the ligand in the Fra a 3-catechin complex. Our findings provide mechanistic insight on the function of Fra a proteins and suggest that PR-10 proteins, which are widespread in plants, may play a role in the control of secondary metabolic pathways by binding to metabolic intermediates." @default.
- W2128446478 created "2016-06-24" @default.
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- W2128446478 date "2013-12-01" @default.
- W2128446478 modified "2023-10-13" @default.
- W2128446478 title "The Strawberry Pathogenesis-related 10 (PR-10) Fra a Proteins Control Flavonoid Biosynthesis by Binding to Metabolic Intermediates" @default.
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- W2128446478 doi "https://doi.org/10.1074/jbc.m113.501528" @default.
- W2128446478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3853281" @default.
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- W2128446478 hasPublicationYear "2013" @default.
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