Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128462886> ?p ?o ?g. }
- W2128462886 endingPage "390" @default.
- W2128462886 startingPage "381" @default.
- W2128462886 abstract "UV irradiation of mammalian cells activates AP-1 through a Ras-dependent pathway, independently of DNA damage. We show that the yeast S. cerevisiae has a remarkably similar UV response involving the AP-1 factor Gcn4, which is distinct from the DNA damage response. Transcriptional activation of HIS3 and HIS4 by Gcn4 is triggered by UV irradiation in a Ras-dependent fashion. Moreover, resistance of yeast to UV irradiation is correlated with the level of Ras activity and Gcn4 function. Like mammalian cells in which activated Ras leads to increased c-Jun synthesis and phosphorylation, the effects in yeast involve increased translation of GCN4 mRNA and a posttranslational event. However, this effect on GCN4 translation is different from the response to amino acid or purine starvation. Therefore, a UV signaling pathway involving Ras and AP-1 is an ancient and universal mechanism involved in protection against damage to cellular components other than DNA." @default.
- W2128462886 created "2016-06-24" @default.
- W2128462886 creator A5024600215 @default.
- W2128462886 creator A5025971831 @default.
- W2128462886 creator A5056315342 @default.
- W2128462886 creator A5083029357 @default.
- W2128462886 creator A5090368346 @default.
- W2128462886 date "1994-05-01" @default.
- W2128462886 modified "2023-09-25" @default.
- W2128462886 title "The UV response involving the ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals" @default.
- W2128462886 cites W1491876634 @default.
- W2128462886 cites W1509317138 @default.
- W2128462886 cites W1757309928 @default.
- W2128462886 cites W175945383 @default.
- W2128462886 cites W1769175751 @default.
- W2128462886 cites W1792328490 @default.
- W2128462886 cites W1818743874 @default.
- W2128462886 cites W1820624545 @default.
- W2128462886 cites W1833690096 @default.
- W2128462886 cites W1876359300 @default.
- W2128462886 cites W1882943721 @default.
- W2128462886 cites W1902685772 @default.
- W2128462886 cites W1909204749 @default.
- W2128462886 cites W1958390418 @default.
- W2128462886 cites W1965429549 @default.
- W2128462886 cites W1968727721 @default.
- W2128462886 cites W1969995482 @default.
- W2128462886 cites W1970497539 @default.
- W2128462886 cites W1971889217 @default.
- W2128462886 cites W1975949180 @default.
- W2128462886 cites W1978798502 @default.
- W2128462886 cites W1981601576 @default.
- W2128462886 cites W1986949138 @default.
- W2128462886 cites W1987189376 @default.
- W2128462886 cites W1987453246 @default.
- W2128462886 cites W1989052124 @default.
- W2128462886 cites W1994975139 @default.
- W2128462886 cites W1995921536 @default.
- W2128462886 cites W2000371106 @default.
- W2128462886 cites W2001248695 @default.
- W2128462886 cites W2003436052 @default.
- W2128462886 cites W2003962192 @default.
- W2128462886 cites W2008014792 @default.
- W2128462886 cites W2014932100 @default.
- W2128462886 cites W2017699383 @default.
- W2128462886 cites W2018432619 @default.
- W2128462886 cites W2022752383 @default.
- W2128462886 cites W2028544954 @default.
- W2128462886 cites W2033421614 @default.
- W2128462886 cites W2037915962 @default.
- W2128462886 cites W2048684469 @default.
- W2128462886 cites W2052654618 @default.
- W2128462886 cites W2057094603 @default.
- W2128462886 cites W2059535670 @default.
- W2128462886 cites W2063960509 @default.
- W2128462886 cites W2064607058 @default.
- W2128462886 cites W2066825851 @default.
- W2128462886 cites W2077880395 @default.
- W2128462886 cites W2078952292 @default.
- W2128462886 cites W2081969062 @default.
- W2128462886 cites W2087085187 @default.
- W2128462886 cites W2090324348 @default.
- W2128462886 cites W2100969531 @default.
- W2128462886 cites W2110374270 @default.
- W2128462886 cites W2113992548 @default.
- W2128462886 cites W2119028299 @default.
- W2128462886 cites W2136140489 @default.
- W2128462886 cites W2137682724 @default.
- W2128462886 cites W2153563795 @default.
- W2128462886 cites W2154192967 @default.
- W2128462886 cites W2159594827 @default.
- W2128462886 cites W23164860 @default.
- W2128462886 cites W2331856524 @default.
- W2128462886 cites W2337500501 @default.
- W2128462886 cites W2414634861 @default.
- W2128462886 cites W2416997007 @default.
- W2128462886 cites W2417705998 @default.
- W2128462886 cites W292063008 @default.
- W2128462886 cites W69547146 @default.
- W2128462886 doi "https://doi.org/10.1016/0092-8674(94)90153-8" @default.
- W2128462886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8181058" @default.
- W2128462886 hasPublicationYear "1994" @default.
- W2128462886 type Work @default.
- W2128462886 sameAs 2128462886 @default.
- W2128462886 citedByCount "210" @default.
- W2128462886 countsByYear W21284628862012 @default.
- W2128462886 countsByYear W21284628862013 @default.
- W2128462886 countsByYear W21284628862014 @default.
- W2128462886 countsByYear W21284628862015 @default.
- W2128462886 countsByYear W21284628862016 @default.
- W2128462886 countsByYear W21284628862018 @default.
- W2128462886 countsByYear W21284628862019 @default.
- W2128462886 countsByYear W21284628862020 @default.
- W2128462886 countsByYear W21284628862021 @default.
- W2128462886 countsByYear W21284628862022 @default.
- W2128462886 countsByYear W21284628862023 @default.
- W2128462886 crossrefType "journal-article" @default.
- W2128462886 hasAuthorship W2128462886A5024600215 @default.