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- W2128469364 abstract "After ejaculation, the mammalian male gamete must undergo the capacitation process, which is a prerequisite for egg fertilization. The bioenergetics of sperm capacitation is poorly understood despite its fundamental role in sustaining the biochemical and molecular events occurring during gamete activation. Glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) are the two major metabolic pathways producing ATP which is the primary source of energy for spermatozoa. Since recent data suggest that spermatozoa have the ability to use different metabolic substrates, the main aim of this work is to present a broad overview of the current knowledge on the energy-producing metabolic pathways operating inside sperm mitochondria during capacitation in different mammalian species. Metabolism of glucose and of other energetic substrates, such as pyruvate, lactate, and citrate, is critically analyzed. Such knowledge, besides its obvious importance for basic science, could eventually translate into the development of novel strategies for treatment of male infertility, artificial reproduction, and sperm selection methods." @default.
- W2128469364 created "2016-06-24" @default.
- W2128469364 creator A5042358406 @default.
- W2128469364 creator A5089132034 @default.
- W2128469364 date "2014-01-01" @default.
- W2128469364 modified "2023-10-01" @default.
- W2128469364 title "Bioenergetics of Mammalian Sperm Capacitation" @default.
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- W2128469364 doi "https://doi.org/10.1155/2014/902953" @default.
- W2128469364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3984864" @default.
- W2128469364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24791005" @default.
- W2128469364 hasPublicationYear "2014" @default.
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