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• W2128492849 abstract "The present study reports elevated levels of endotoxin/lipopolysaccharide (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation with degree of blood monocyte/macrophage activation in disease groups and was most elevated in patients with advanced sALS disease. There was a significant negative relationship between plasma LPS and levels of monocyte/macrophage IL-10 expression in sALS blood. These data suggest that systemic LPS levels and activated monocyte/macrophages may play significant roles in the pathogenesis of sALS." @default.
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• W2128492849 date "2009-01-01" @default.
• W2128492849 modified "2023-10-14" @default.
• W2128492849 title "Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)" @default.
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• W2128492849 doi "https://doi.org/10.1016/j.jneuroim.2008.09.017" @default.
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