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• W2128502044 abstract "Stimulation of CD27, a member of the tumour necrosis factor receptor family, by its ligand CD70 induces expansion of IFNγ secreting CD4+ and CD8+ T cells in vivo. We here analysed the mechanisms through which CD27 mediates this effect. CD27 co-stimulation induced cell division but did not directly instruct naive CD4+ T cells to differentiate into IFNγ-producing Th1 cells. Rather, in concert with signals delivered through the TCR–CD3 complex, CD27 co-stimulation enhanced the Th1-specific transcription factor T-bet and caused up-regulation of the IL-12Rbeta2 chain. Consequently, CD27-costimulated T cells yielded vast numbers of IFNγ-secreting cells in response to IL-12. Additionally, CD27 ligation induced a strong up-regulation of Bcl-xL, but not of related anti-apoptotic molecules. Thus, CD27–CD70 interactions may promote Th1 formation by permitting naive T cells to respond to differentiation signals and by promoting survival of activated effector T cells." @default.
• W2128502044 created "2016-06-24" @default.
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• W2128502044 date "2007-05-09" @default.
• W2128502044 modified "2023-10-07" @default.
• W2128502044 title "CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development" @default.
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• W2128502044 doi "https://doi.org/10.1093/intimm/dxm033" @default.
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