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- W2128507230 endingPage "C450" @default.
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- W2128507230 abstract "The role of G protein-coupled receptors and their ligands in intestinal epithelial cell signaling and proliferation is poorly understood. Here, we demonstrate that arginine vasopressin (AVP) induces multiple intracellular signal transduction pathways in rat intestinal epithelial IEC-18 cells via a V 1A receptor. Addition of AVP to these cells induces a rapid and transient increase in cytosolic Ca 2+ concentration and promotes protein kinase D (PKD) activation through a protein kinase C (PKC)-dependent pathway, as revealed by in vitro kinase assays and immunoblotting with an antibody that recognizes autophosphorylated PKD at Ser 916 . AVP also stimulates the tyrosine phosphorylation of the nonreceptor tyrosine kinase proline-rich tyrosine kinase 2 (Pyk2) and promotes Src family kinase phosphorylation at Tyr 418 , indicative of Src activation. AVP induces extracellular signal-related kinase (ERK)-1 (p44 mapk ) and ERK-2 (p42 mapk ) activation, a response prevented by treatment with mitogen-activated protein kinase kinase (MEK) inhibitors (PD-98059 and U-0126), specific PKC inhibitors (GF-I and Ro-31-8220), depletion of Ca 2+ (EGTA and thapsigargin), selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (tyrphostin AG-1478, compound 56), or the selective Src family kinase inhibitor PP-2. Furthermore, AVP acts as a potent growth factor for IEC-18 cells, inducing DNA synthesis and cell proliferation through ERK-, Ca 2+ -, PKC-, EGFR tyrosine kinase-, and Src-dependent pathways." @default.
- W2128507230 created "2016-06-24" @default.
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- W2128507230 date "2002-03-01" @default.
- W2128507230 modified "2023-09-25" @default.
- W2128507230 title "Vasopressin-mediated mitogenic signaling in intestinal epithelial cells" @default.
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- W2128507230 doi "https://doi.org/10.1152/ajpcell.00240.2001" @default.
- W2128507230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11832328" @default.
- W2128507230 hasPublicationYear "2002" @default.
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