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• W2128509780 abstract "Sirtuins (SIRTs) are a family of histone deacetylases, targeting a ­multitude of histone but also nonhistone proteins. Via a nicotinamide adenine dinucle­otide-dependent deacetylation reaction, sirtuins regulate the activity of transcription factors important for cell proliferation, apoptosis, and cell metabolism. In particular, the finding that SIRT1 mediates the life-prolonging effects of calorie restriction has highlighted the crucial role of sirtuins in cellular homeostasis. In addition, sirtuins have been shown to affect the immune system by targeting transcription factors such as nuclear factor-κB (NFκB). Effects on inflammation have been demonstrated in SIRT1-deficient mice which show increased transcription of proinflammatory cytokines and display a systemic lupus erythematosus-like phenotype. Data on the role of sirtuins in arthritis are only beginning to emerge. In this review, we summarize recent findings on the expression and ­function of sirtuins in rheumatoid arthritis and osteoarthritis." @default.
• W2128509780 created "2016-06-24" @default.
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• W2128509780 date "2012-12-24" @default.
• W2128509780 modified "2023-09-25" @default.
• W2128509780 title "The Role of Sirtuins in Arthritis" @default.
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• W2128509780 doi "https://doi.org/10.1007/978-1-4614-6166-1_18" @default.
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