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• W2128517699 abstract "Toll-like receptors (TLRs) are expressed on all major subsets of liver cells. Both exogenous ligands derived from pathogens, and endogenous ligands that are products of cellular injury, engage these receptors and activate aspects of innate immunity. These receptors play a role in viral and parasitic infections of the liver, in ischemia-reperfusion injury, and in toxic liver damage, promoting antipathogen immunity but also hepatocellular injury and fibrogenesis. However, TLRs may also participate in negative feedback that limits tissue injury. In the complex environment of the liver, TLRs participate in pathologic cascades involving multiple cell types, manifesting their effects both through cell-autonomous actions, and via cellular crosstalk. In this paper we survey the involvement of TLRs in these diverse processes." @default.
• W2128517699 created "2016-06-24" @default.
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• W2128517699 date "2010-01-01" @default.
• W2128517699 modified "2023-09-27" @default.
• W2128517699 title "TLRs in Hepatic Cellular Crosstalk" @default.
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• W2128517699 doi "https://doi.org/10.1155/2010/618260" @default.
• W2128517699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2939438" @default.
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