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• W2128540650 abstract "Two populations of CD8+ IEL generally express restricted, but apparently random and non-overlapping TCR repertoires. Previous studies in mice suggested that this could be explained by a dual origin of CD8+ IEL, i.e. that CD8αβ+ IEL derive from a few peripheral CD8+ T cell lymphoblasts stimulated by microbial antigens in gut-associated lymphoid tissue, whereas CD8αα+ IEL descend from an inefficient intestinal maturation pathway. We show here that the gut mucosa, instead, becomes seeded with surprisingly broad and generally non-overlapping CD8 IEL repertoires and that oligoclonality is induced locally after microbial colonization. In germ-free (GF) rats, both CD8αβ+ and CD8αα+ IEL displayed surprisingly diverse TCR Vβ repertoires, although β-chain diversity tended to be somewhat restricted in the CD8αα+ subset. CDR3 length displays in individual Vβ-Cβ and Vβ-Jβ combinations generally revealed polyclonal distributions over 6–11 different lengths, similar to CD8+ lymph node T cells, and CDR3β sequencing provided further documentation of repertoire diversity. By contrast, in ex-GF rats colonized with normal commensal microflora, both CD8αβ+ and CD8αα+ IEL displayed oligoclonal CDR3 length distributions for most of the Vβ genes analyzed. Our data suggest that microbial colonization induces apparently random clonal expansions of CD8αβ+ and CD8αα+ IEL locally in the gut." @default.
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• W2128540650 date "2004-12-01" @default.
• W2128540650 modified "2023-10-16" @default.
• W2128540650 title "Microbial colonization induces oligoclonal expansions of intraepithelial CD8 T cells in the gut" @default.
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• W2128540650 doi "https://doi.org/10.1002/eji.200425122" @default.
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