FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128541738> ?p ?o ?g. }

• W2128541738 endingPage "1079" @default.
• W2128541738 startingPage "1069" @default.
• W2128541738 abstract "Previous studies demonstrated that a subset of synMuv B mutants ectopically misexpress germline-specific P-granule proteins in their somatic cells, suggesting a failure to properly orchestrate a soma/germline fate decision. Surprisingly, this fate confusion does not affect viability at low to ambient temperatures. Here, we show that, when grown at high temperature, a majority of synMuv B mutants irreversibly arrest at the L1 stage. High temperature arrest (HTA) is accompanied by upregulation of many genes characteristic of germ line, including genes encoding components of the synaptonemal complex and other meiosis proteins. HTA is suppressed by loss of global regulators of germline chromatin, including MES-4, MRG-1, ISW-1 and the MES-2/3/6 complex, revealing that arrest is caused by somatic cells possessing a germline-like chromatin state. Germline genes are preferentially misregulated in the intestine, and necessity and sufficiency tests demonstrate that the intestine is the tissue responsible for HTA. We propose that synMuv B mutants fail to erase or antagonize an inherited germline chromatin state in somatic cells during embryonic and early larval development. As a consequence, somatic cells gain a germline program of gene expression in addition to their somatic program, leading to a mixed fate. Somatic expression of germline genes is enhanced at elevated temperature, leading to developmentally compromised somatic cells and arrest of newly hatched larvae." @default.
• W2128541738 created "2016-06-24" @default.
• W2128541738 creator A5014867821 @default.
• W2128541738 creator A5018304015 @default.
• W2128541738 creator A5057955464 @default.
• W2128541738 creator A5062755510 @default.
• W2128541738 creator A5073502597 @default.
• W2128541738 creator A5077544133 @default.
• W2128541738 date "2011-03-15" @default.
• W2128541738 modified "2023-10-18" @default.
• W2128541738 title "synMuv B proteins antagonize germline fate in the intestine and ensure <i>C. elegans</i> survival" @default.
• W2128541738 cites W1901723783 @default.
• W2128541738 cites W1944127002 @default.
• W2128541738 cites W1963937022 @default.
• W2128541738 cites W1965532812 @default.
• W2128541738 cites W1971954646 @default.
• W2128541738 cites W1972247295 @default.
• W2128541738 cites W1975542747 @default.
• W2128541738 cites W1978427659 @default.
• W2128541738 cites W1981620468 @default.
• W2128541738 cites W1982159610 @default.
• W2128541738 cites W1989952069 @default.
• W2128541738 cites W2011998227 @default.
• W2128541738 cites W2016542199 @default.
• W2128541738 cites W2017566669 @default.
• W2128541738 cites W2023771701 @default.
• W2128541738 cites W2024523631 @default.
• W2128541738 cites W2027495004 @default.
• W2128541738 cites W2028839214 @default.
• W2128541738 cites W2031361194 @default.
• W2128541738 cites W2033507657 @default.
• W2128541738 cites W2037102374 @default.
• W2128541738 cites W2049427149 @default.
• W2128541738 cites W2051862923 @default.
• W2128541738 cites W2061424667 @default.
• W2128541738 cites W2061710204 @default.
• W2128541738 cites W2070355572 @default.
• W2128541738 cites W2076580711 @default.
• W2128541738 cites W2088285982 @default.
• W2128541738 cites W2098745876 @default.
• W2128541738 cites W2099950781 @default.
• W2128541738 cites W2104800372 @default.
• W2128541738 cites W2104933707 @default.
• W2128541738 cites W2107739100 @default.
• W2128541738 cites W2125256388 @default.
• W2128541738 cites W2128491398 @default.
• W2128541738 cites W2134895772 @default.
• W2128541738 cites W2136670802 @default.
• W2128541738 cites W2138301522 @default.
• W2128541738 cites W2149295230 @default.
• W2128541738 cites W2150852081 @default.
• W2128541738 cites W2152105724 @default.
• W2128541738 cites W2155103279 @default.
• W2128541738 cites W2155328400 @default.
• W2128541738 cites W2168657675 @default.
• W2128541738 cites W2170728578 @default.
• W2128541738 cites W219883212 @default.
• W2128541738 doi "https://doi.org/10.1242/dev.059501" @default.
• W2128541738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3042865" @default.
• W2128541738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21343362" @default.
• W2128541738 hasPublicationYear "2011" @default.
• W2128541738 type Work @default.
• W2128541738 sameAs 2128541738 @default.
• W2128541738 citedByCount "83" @default.
• W2128541738 countsByYear W21285417382012 @default.
• W2128541738 countsByYear W21285417382013 @default.
• W2128541738 countsByYear W21285417382014 @default.
• W2128541738 countsByYear W21285417382015 @default.
• W2128541738 countsByYear W21285417382016 @default.
• W2128541738 countsByYear W21285417382017 @default.
• W2128541738 countsByYear W21285417382018 @default.
• W2128541738 countsByYear W21285417382019 @default.
• W2128541738 countsByYear W21285417382020 @default.
• W2128541738 countsByYear W21285417382021 @default.
• W2128541738 countsByYear W21285417382022 @default.
• W2128541738 countsByYear W21285417382023 @default.
• W2128541738 crossrefType "journal-article" @default.
• W2128541738 hasAuthorship W2128541738A5014867821 @default.
• W2128541738 hasAuthorship W2128541738A5018304015 @default.
• W2128541738 hasAuthorship W2128541738A5057955464 @default.
• W2128541738 hasAuthorship W2128541738A5062755510 @default.
• W2128541738 hasAuthorship W2128541738A5073502597 @default.
• W2128541738 hasAuthorship W2128541738A5077544133 @default.
• W2128541738 hasBestOaLocation W21285417381 @default.
• W2128541738 hasConcept C104317684 @default.
• W2128541738 hasConcept C109825262 @default.
• W2128541738 hasConcept C134305767 @default.
• W2128541738 hasConcept C13514818 @default.
• W2128541738 hasConcept C143065580 @default.
• W2128541738 hasConcept C2778944004 @default.
• W2128541738 hasConcept C501734568 @default.
• W2128541738 hasConcept C54355233 @default.
• W2128541738 hasConcept C83640560 @default.
• W2128541738 hasConcept C86803240 @default.
• W2128541738 hasConcept C95444343 @default.
• W2128541738 hasConceptScore W2128541738C104317684 @default.
• W2128541738 hasConceptScore W2128541738C109825262 @default.
• W2128541738 hasConceptScore W2128541738C134305767 @default.

• next