FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128543124> ?p ?o ?g. }

• W2128543124 endingPage "629" @default.
• W2128543124 startingPage "619" @default.
• W2128543124 abstract "Abstract Under normal conditions, macrophages provide essential innate immune surveillance in tissues. These cells also play key functions during wound healing and in pathological conditions. When macrophages are exposed to thrombin, an enzyme released from leaky blood vessels, they are stimulated to produce inflammatory cytokines, which are critical for wound healing and can also facilitate tumor growth and invasion. Using antibody cytokine arrays, we identified IL-8/CXCL8, a chemokine that plays important functions in inflammation and angiogenesis and consequently in healing and tumor development, as one of the cytokines that is highly stimulated in macrophages by thrombin. Here, we investigated the signal transduction mechanism by which thrombin stimulates IL-8/CXCL8 expression in THP-1-derived and primary human macrophags. We show that JNK is a crucial mediator of the thrombin signaling pathways in macrophages, and the activation of JNK is dependent on stimulation of the Rho small GTPase. The thrombin-induced Rho/JNK cascade is a novel signaling cascade for IL-8/CXCL8 transcription activation. Understanding the molecular mechanism by which thrombin controls the expression of inflammatory cytokines in macrophages can lead to therapeutic interventions, which can provide better management of healing, inflammation, and tumorigenesis." @default.
• W2128543124 created "2016-06-24" @default.
• W2128543124 creator A5003079948 @default.
• W2128543124 creator A5060309212 @default.
• W2128543124 date "2007-06-22" @default.
• W2128543124 modified "2023-10-18" @default.
• W2128543124 title "Molecular mechanisms of thrombin-induced interleukin-8 (IL-8/CXCL8) expression in THP-1-derived and primary human macrophages" @default.
• W2128543124 cites W1500151013 @default.
• W2128543124 cites W1506589985 @default.
• W2128543124 cites W1515730558 @default.
• W2128543124 cites W1551086383 @default.
• W2128543124 cites W1563055005 @default.
• W2128543124 cites W1592606160 @default.
• W2128543124 cites W1655390247 @default.
• W2128543124 cites W1811402656 @default.
• W2128543124 cites W1825815388 @default.
• W2128543124 cites W1963902937 @default.
• W2128543124 cites W1973635213 @default.
• W2128543124 cites W1973799328 @default.
• W2128543124 cites W1979946302 @default.
• W2128543124 cites W1980300702 @default.
• W2128543124 cites W1993046527 @default.
• W2128543124 cites W1997500769 @default.
• W2128543124 cites W2011214577 @default.
• W2128543124 cites W2029790299 @default.
• W2128543124 cites W2035262124 @default.
• W2128543124 cites W2039727622 @default.
• W2128543124 cites W2066963386 @default.
• W2128543124 cites W2076485183 @default.
• W2128543124 cites W2087838991 @default.
• W2128543124 cites W2101791639 @default.
• W2128543124 cites W2110105332 @default.
• W2128543124 cites W2112668385 @default.
• W2128543124 cites W2125049729 @default.
• W2128543124 cites W2127309246 @default.
• W2128543124 cites W2130920291 @default.
• W2128543124 cites W2144814682 @default.
• W2128543124 cites W2145028653 @default.
• W2128543124 cites W2147921405 @default.
• W2128543124 cites W2148119611 @default.
• W2128543124 cites W2151588652 @default.
• W2128543124 cites W2156359770 @default.
• W2128543124 cites W2158084518 @default.
• W2128543124 cites W2171003020 @default.
• W2128543124 doi "https://doi.org/10.1189/jlb.0107009" @default.
• W2128543124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17586662" @default.
• W2128543124 hasPublicationYear "2007" @default.
• W2128543124 type Work @default.
• W2128543124 sameAs 2128543124 @default.
• W2128543124 citedByCount "23" @default.
• W2128543124 countsByYear W21285431242012 @default.
• W2128543124 countsByYear W21285431242013 @default.
• W2128543124 countsByYear W21285431242014 @default.
• W2128543124 countsByYear W21285431242015 @default.
• W2128543124 countsByYear W21285431242016 @default.
• W2128543124 countsByYear W21285431242018 @default.
• W2128543124 countsByYear W21285431242020 @default.
• W2128543124 crossrefType "journal-article" @default.
• W2128543124 hasAuthorship W2128543124A5003079948 @default.
• W2128543124 hasAuthorship W2128543124A5060309212 @default.
• W2128543124 hasBestOaLocation W21285431241 @default.
• W2128543124 hasConcept C13373296 @default.
• W2128543124 hasConcept C164027704 @default.
• W2128543124 hasConcept C203014093 @default.
• W2128543124 hasConcept C2776914184 @default.
• W2128543124 hasConcept C2777292125 @default.
• W2128543124 hasConcept C2778690821 @default.
• W2128543124 hasConcept C2780269544 @default.
• W2128543124 hasConcept C2780394083 @default.
• W2128543124 hasConcept C502942594 @default.
• W2128543124 hasConcept C62478195 @default.
• W2128543124 hasConcept C68324877 @default.
• W2128543124 hasConcept C86803240 @default.
• W2128543124 hasConcept C89560881 @default.
• W2128543124 hasConcept C95444343 @default.
• W2128543124 hasConceptScore W2128543124C13373296 @default.
• W2128543124 hasConceptScore W2128543124C164027704 @default.
• W2128543124 hasConceptScore W2128543124C203014093 @default.
• W2128543124 hasConceptScore W2128543124C2776914184 @default.
• W2128543124 hasConceptScore W2128543124C2777292125 @default.
• W2128543124 hasConceptScore W2128543124C2778690821 @default.
• W2128543124 hasConceptScore W2128543124C2780269544 @default.
• W2128543124 hasConceptScore W2128543124C2780394083 @default.
• W2128543124 hasConceptScore W2128543124C502942594 @default.
• W2128543124 hasConceptScore W2128543124C62478195 @default.
• W2128543124 hasConceptScore W2128543124C68324877 @default.
• W2128543124 hasConceptScore W2128543124C86803240 @default.
• W2128543124 hasConceptScore W2128543124C89560881 @default.
• W2128543124 hasConceptScore W2128543124C95444343 @default.
• W2128543124 hasFunder F4320323217 @default.
• W2128543124 hasFunder F4320332550 @default.
• W2128543124 hasIssue "3" @default.
• W2128543124 hasLocation W21285431241 @default.
• W2128543124 hasLocation W21285431242 @default.
• W2128543124 hasOpenAccess W2128543124 @default.
• W2128543124 hasPrimaryLocation W21285431241 @default.
• W2128543124 hasRelatedWork W1982639133 @default.
• W2128543124 hasRelatedWork W1995170023 @default.

• next